Alkynyl Moiety for Triggering 1,2‐Metallate Shifts: Enantiospecific sp 2 –sp 3 Coupling of Boronic Esters with p ‐Arylacetylenes
Abstract: The enantiospecific coupling of secondary and tertiary boronic esters to aromatics has been investigated. Using p‐lithiated phenylacetylenes and a range of boronic esters coupling has been achieved by the addition of N‐bromosuccinimide (NBS). The alkyne functionality of the intermediate boronate complex reacts with NBS triggering the 1,2‐migration of the group on boron to carbon giving a dearomatized bromoallene intermediate. At this point elimination and rearomatization occurs with neopentyl boronic esters, giving the coupled products. However, using pinacol boronic esters, the boron moiety migrates to the adjacent carbon resulting in formation of ortho boron‐incorporated coupled products. The synthetic utility of the boron incorporated product has been demonstrated by orthogonal transformation of both the alkyne and boronic ester functionalities.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Alkynyl Moiety for Triggering 1,2‐Metallate Shifts: Enantiospecific sp 2 –sp 3 Coupling of Boronic Esters with p ‐Arylacetylenes ; volume:129 ; number:33 ; year:2017 ; pages:9884-9888 ; extent:5
Angewandte Chemie ; 129, Heft 33 (2017), 9884-9888 (gesamt 5)
- Urheber
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Ganesh, Venkataraman
Odachowski, Marcin
Aggarwal, Varinder K.
- DOI
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10.1002/ange.201703894
- URN
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urn:nbn:de:101:1-2022091608581197114017
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:32 MESZ
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Beteiligte
- Ganesh, Venkataraman
- Odachowski, Marcin
- Aggarwal, Varinder K.
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