Pre-emptive paracetamol reduces intra-operative opioid use in patients undergoing day-case oncologic breast surgery

Abstract: Minimization of intra-operative opioid use is an area of ongoing research interest with several potential benefits to the patient. Pre-emptive analgesia, defined as the administration of an analgesic before surgery to prevent establishment of central sensitization of pain, is one avenue that has been explored to achieve this. A retrospective observational study was undertaken to examine the effect of pre-emptive paracetamol on intra-operative opioid requirements. The medical and operative data of 156 patients who underwent day-case wide local excision and sentinel lymph node biopsy with and without regional block surgery at our center between October 2019 and May 2022 was carried out. Data were collected on demographics, total intra-operative and immediate post-operative opioid consumption. 57 patients did not receive pre-emptive paracetamol while 90 did. Baseline characteristics were similar. Our results showed a statistically significant reduction in morphine (p <0.029) and remif.... https://www.excli.de/index.php/excli/article/view/6804

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Pre-emptive paracetamol reduces intra-operative opioid use in patients undergoing day-case oncologic breast surgery ; volume:23 ; year:2024 ; EXCLI journal ; 23 (2024)

Beteiligte, Orts- und Zeitangaben

• Urheber: Alsaadi, Daniah ; Low, Lyndon ; Ting, James ; Craughwell, Michael ; McDonnell, John ; Lowery, Aoife ; Sweeney, Karl

Weitere Informationen

• DOI: 10.17179/excli2023-6804
• URN: urn:nbn:de:101:1-2406210314216.820493339297
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:57 MESZ