A 2D Nanoradiosensitizer Enhances Radiotherapy and Delivers STING Agonists to Potentiate Cancer Immunotherapy
Abstract: Despite potent preclinical antitumor activity, activation of stimulator of interferon genes (STING) has shown modest therapeutic effects in clinical studies. Many STING agonists, including 2′,3′‐cyclic guanosine monophosphate–adenosine monophosphate (cGAMP), show poor pharmacokinetic properties for sustaining STING activation in tumors and achieving optimal antitumor efficacy. Improved delivery of STING agonists and their effective combination with other treatments are needed to enhance their therapeutic effects. Herein, a 2D nanoplatform, cGAMP/MOL, is reported via conjugating cGAMP to a nanoscale metal–organic layer (MOL) for simultaneous STING activation and radiosensitization. The MOL not only exhibits strong radiosensitization effects for enhanced cancer killing and induction of immunogenic cell death, but also retains cGAMP in tumors for sustained STING activation. Compared to free cGAMP, cGAMP/MOL elicits stronger STING activation and regresses local tumors upon X‐ray irradiation. Further combination with an immune checkpoint inhibitor bridges innate and adaptive immune systems by activating the tumor microenvironment to elicit systemic antitumor responses.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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A 2D Nanoradiosensitizer Enhances Radiotherapy and Delivers STING Agonists to Potentiate Cancer Immunotherapy ; day:26 ; month:08 ; year:2022 ; extent:12
Advanced materials ; (26.08.2022) (gesamt 12)
- Creator
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Luo, Taokun
Nash, Geoffrey T.
Jiang, Xiaomin
Feng, Xuanyu
Mao, Jianming
Liu, Jianqiao
Juloori, Aditya
Pearson, Alexander T.
Lin, Wenbin
- DOI
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10.1002/adma.202110588
- URN
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urn:nbn:de:101:1-2022083015085392503298
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:32 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Luo, Taokun
- Nash, Geoffrey T.
- Jiang, Xiaomin
- Feng, Xuanyu
- Mao, Jianming
- Liu, Jianqiao
- Juloori, Aditya
- Pearson, Alexander T.
- Lin, Wenbin
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Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy
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PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling
ZC3HAV1 facilitates STING activation and enhances inflammation
Responsive Multivesicular Polymeric Nanovaccines that Codeliver STING Agonists and Neoantigens for Combination Tumor Immunotherapy
Precisely Activating cGAS‐STING Pathway with a Novel Peptide‐Based Nanoagonist to Potentiate Immune Checkpoint Blockade Cancer Immunotherapy
Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy
Repolarizing neutrophils via MnO2 nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy
Bifunctional Metal–Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy
Bifunctional Metal–Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy
BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition
Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy
Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists
A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists
PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling