Improving the Photodynamic Activity of Water‐Soluble Porphyrin–Polysaccharide Complexes by Folic Acid Modification
Abstract: Studies have shown that folate receptors are highly expressed in various cancer cells. Here, we synthesized folic acid‐conjugated pullulan (FAPL) as a solubilizing agent to improve the photodynamic activity of porphyrin derivative–polysaccharide complexes. The porphyrin derivative–FAPL complex exhibited long‐term stability in an aqueous solution, attributed to the folic acid modification. Furthermore, in vitro and in vivo experiments highlighted the enhanced photodynamic activity of the porphyrin derivative–FAPL complex toward 4T1 breast‐cancer cells, compared with the activities of the porphyrin derivative–pullulan complex and Photofrin. This enhanced activity is attributed to the improvement of intracellular uptake by the folate receptor.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Improving the Photodynamic Activity of Water‐Soluble Porphyrin–Polysaccharide Complexes by Folic Acid Modification ; day:20 ; month:08 ; year:2024 ; extent:9
ChemMedChem ; (20.08.2024) (gesamt 9)
- Creator
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Nishimura, Kotaro
Kono, Nanami
Oshige, Ayano
Takahashi, Haruko
Yamana, Keita
Kawasaki, Riku
Ikeda, Atsushi
- DOI
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10.1002/cmdc.202400268
- URN
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urn:nbn:de:101:1-2408211428163.643777776967
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:51 AM CEST
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Associated
- Nishimura, Kotaro
- Kono, Nanami
- Oshige, Ayano
- Takahashi, Haruko
- Yamana, Keita
- Kawasaki, Riku
- Ikeda, Atsushi
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Porphyrin-lipid stabilized paclitaxel nanoemulsion for combined photodynamic therapy and chemotherapy
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