Molecularly Imprinted Nanobeacons Redirect Innate Immune Killing towards Triple Negative Breast Cancer

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Abstract: Harnessing innate immunity is an appealing strategy for cancer treatment. Herein, we report a new strategy called molecularly imprinted nanobeacons (MINBs) for redirecting innate immune killing towards triple‐negative breast cancer (TNBC). The MINBs were molecularly imprinted nanoparticles with the N‐epitope of glycoprotein nonmetastatic B (GPNMB) as the template and grafted with plentiful fluorescein moieties as the hapten. The MINBs could tag the TNBC cells via binding with GPNMB and thereby provide navigation for recruiting hapten‐specific antibodies. The gathered antibodies could further trigger effective Fc‐domain‐mediated immune killing towards the tagged cancer cells. In vivo experiments showed that the TNBC growth was significantly inhibited after MINBs treatment by intravenous injection as compared with control groups. This study not only opens a new access for redirecting innate immunity towards TNBC but also paves the way for innate immunity‐based therapy of other diseases.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Molecularly Imprinted Nanobeacons Redirect Innate Immune Killing towards Triple Negative Breast Cancer ; day:10 ; month:03 ; year:2023 ; extent:11
Angewandte Chemie / International edition. International edition ; (10.03.2023) (gesamt 11)

Creator: Guan, Peixin
Guo, Zhanchen
Xu, Shuxin
Lu, Haifeng
Wang, Lisheng
Gu, Zikuan
Liu, Zhen

DOI: 10.1002/anie.202301202

URN: urn:nbn:de:101:1-2023031014172206447723

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:48 AM CEST

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Guan, Peixin
Guo, Zhanchen
Xu, Shuxin
Lu, Haifeng
Wang, Lisheng
Gu, Zikuan
Liu, Zhen

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Molecularly Imprinted Nanobeacons Redirect Innate Immune Killing towards Triple Negative Breast Cancer

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Other Objects (12)

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