Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice
Insufficient sleep compromises lipid/glucose homeostasis. In opposition, exercise increases energy expenditure and has positive effects on glucose and fatty acid metabolism. Presently, it is hypothesized that exercise ameliorates metabolic dysfunction associated with sleep deprivation (SD). The effects of exercise (EX), SD and EX before SD. (EX+SD) on lipid and glucose metabolism were evaluated. Swiss mice were assigned to 4 groups (N=12, each) control, exercise (EX, 8 weeks, 1-hour of treadmill/9cm/s, 5x/week, from noon to 1:00 p.m.), SD (SD-72h, multiple platforms method), and exercise before SD (EX+SD). Exercise increased blood glucose, lactate and triglycerides (p<0.05). Both, SD and EX+SD reduced blood triglycerides (p<0.05). EX increased VLDL and reduced LDL; conversely, SD and EX+SD reduced VLDL and increased LDL. Hepatic triglycerides were markedly reduced by SD (p<0.05) and this was prevented by previous exercise (EX+SD). In summary, exercise improved essential cholesterol fractions and exercise before SD increased hepatic cholesterol and prevented hepatic triglycerides depletion.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Exercise modifies lipid and glucose metabolism alterations induced by sleep deprivation in mice ; volume:15 ; number:03 ; year:2022 ; pages:347-350
Sleep science ; 15, Heft 03 (2022), 347-350
- Contributor
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Silva, Bruna Rafaele Diogenes da
Nunes, Paulo Iury Gomes
Santos, Flavia Almeida
Bruin, Pedro Felipe Carvalhedo de
Bruin, Veralice Meireles Sales de
- DOI
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10.5935/1984-0063.20220061
- URN
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urn:nbn:de:101:1-2024011810543630763278
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:37 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Silva, Bruna Rafaele Diogenes da
- Nunes, Paulo Iury Gomes
- Santos, Flavia Almeida
- Bruin, Pedro Felipe Carvalhedo de
- Bruin, Veralice Meireles Sales de
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