Kinetic control of parallel versus antiparallel amyloid aggregation via shape of the growing aggregate

to related objects

Abstract: By combining atomistic and higher-level modelling with solution X-ray diffraction we analyse self-assembly pathways for the IFQINS hexapeptide, a bio-relevant amyloid former derived from human lysozyme. We verify that (at least) two metastable polymorphic structures exist for this system which are substantially different at the atomistic scale, and compare the conditions under which they are kinetically accessible. We further examine the higher-level polymorphism for these systems at the nanometre to micrometre scales, which is manifested in kinetic differences and in shape differences between structures instead of or as well as differences in the small-scale contact topology. Any future design of structure based inhibitors of the IFQINS steric zipper, or of close homologues such as TFQINS which are likely to have similar structures, should take account of this polymorphic assembly

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Scientific reports. - 9, 1 (2019) , ISSN: 2045-2322

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2020

Creator: Zanjani, Ali Asghar Hakami
Reynolds, Nicholas P.
Zhang, Afang
Schilling, Tanja
Mezzenga, Raffaele
Berryman, Joshua T.

Contributor: Arbeitsgruppe Statistische Physik Weicher Materie und Komplexer Systeme

DOI: 10.1038/s41598-019-52238-x

URN: urn:nbn:de:bsz:25-freidok-1709506

Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:46 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Zanjani, Ali Asghar Hakami
Reynolds, Nicholas P.
Zhang, Afang
Schilling, Tanja
Mezzenga, Raffaele
Berryman, Joshua T.
Arbeitsgruppe Statistische Physik Weicher Materie und Komplexer Systeme
Universität

Time of origin

2020

Other Objects (12)

Aggregation des Amyloid-β-Peptids : Einfluss von Fluorophoren, Aggregationskinetik und Thermostabilität der Aggregate

Hochschulschrift

Folding and aggregation of amyloid peptides

Amyloid and Amyloid-Like Aggregates: Diversity and the Term Crisis

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

Oxidation destabilizes toxic amyloid beta peptide aggregation

Endothelial leakiness elicited by amyloid protein aggregation

Amyloid‐Like Protein Aggregation Toward Pesticide Reduction

Protein thermal sensing regulates physiological amyloid aggregation

Forecasting contemporaneous aggregates with stochastic aggregation weights

Hochschulschrift

Inhibitoren der AChE, BuChE und der Amyloid-β-Aggregation [Amyloid-Beta-Aggregation] vom Pyridylenhydrazon-Typ

Aggregation des Amyloid-β-Peptids : Einfluss von Fluorophoren, Aggregationskinetik und Thermostabilität der Aggregate

Hochschulschrift

Folding and aggregation of amyloid peptides

Amyloid and Amyloid-Like Aggregates: Diversity and the Term Crisis

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

Oxidation destabilizes toxic amyloid beta peptide aggregation

Endothelial leakiness elicited by amyloid protein aggregation

Amyloid‐Like Protein Aggregation Toward Pesticide Reduction

Protein thermal sensing regulates physiological amyloid aggregation

Forecasting contemporaneous aggregates with stochastic aggregation weights

Hochschulschrift

Inhibitoren der AChE, BuChE und der Amyloid-β-Aggregation [Amyloid-Beta-Aggregation] vom Pyridylenhydrazon-Typ

Aggregation des Amyloid-β-Peptids : Einfluss von Fluorophoren, Aggregationskinetik und Thermostabilität der Aggregate

Hochschulschrift

Folding and aggregation of amyloid peptides

Amyloid and Amyloid-Like Aggregates: Diversity and the Term Crisis

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

Oxidation destabilizes toxic amyloid beta peptide aggregation

Endothelial leakiness elicited by amyloid protein aggregation

Amyloid‐Like Protein Aggregation Toward Pesticide Reduction

Protein thermal sensing regulates physiological amyloid aggregation

Forecasting contemporaneous aggregates with stochastic aggregation weights

Hochschulschrift

Inhibitoren der AChE, BuChE und der Amyloid-β-Aggregation [Amyloid-Beta-Aggregation] vom Pyridylenhydrazon-Typ

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

Kinetic control of parallel versus antiparallel amyloid aggregation via shape of the growing aggregate

Object Details

Contributors, Places and Time

Further information

Data provider

Associated

Time of origin

Other Objects (12)

Aggregation des Amyloid-β-Peptids : Einfluss von Fluorophoren, Aggregationskinetik und Thermostabilität der Aggregate

Folding and aggregation of amyloid peptides

Amyloid and Amyloid-Like Aggregates: Diversity and the Term Crisis

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

Oxidation destabilizes toxic amyloid beta peptide aggregation

Endothelial leakiness elicited by amyloid protein aggregation

Amyloid‐Like Protein Aggregation Toward Pesticide Reduction

Protein thermal sensing regulates physiological amyloid aggregation

Forecasting contemporaneous aggregates with stochastic aggregation weights

Forecasting contemporaneous aggregates with stochastic aggregation weights

Inhibitoren der AChE, BuChE und der Amyloid-β-Aggregation [Amyloid-Beta-Aggregation] vom Pyridylenhydrazon-Typ

Aggregation des Amyloid-β-Peptids : Einfluss von Fluorophoren, Aggregationskinetik und Thermostabilität der Aggregate

Folding and aggregation of amyloid peptides

Amyloid and Amyloid-Like Aggregates: Diversity and the Term Crisis

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

Oxidation destabilizes toxic amyloid beta peptide aggregation

Endothelial leakiness elicited by amyloid protein aggregation

Amyloid‐Like Protein Aggregation Toward Pesticide Reduction

Protein thermal sensing regulates physiological amyloid aggregation

Forecasting contemporaneous aggregates with stochastic aggregation weights

Forecasting contemporaneous aggregates with stochastic aggregation weights

Inhibitoren der AChE, BuChE und der Amyloid-β-Aggregation [Amyloid-Beta-Aggregation] vom Pyridylenhydrazon-Typ

Aggregation des Amyloid-β-Peptids : Einfluss von Fluorophoren, Aggregationskinetik und Thermostabilität der Aggregate

Folding and aggregation of amyloid peptides

Amyloid and Amyloid-Like Aggregates: Diversity and the Term Crisis

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

Oxidation destabilizes toxic amyloid beta peptide aggregation

Endothelial leakiness elicited by amyloid protein aggregation

Amyloid‐Like Protein Aggregation Toward Pesticide Reduction

Protein thermal sensing regulates physiological amyloid aggregation

Forecasting contemporaneous aggregates with stochastic aggregation weights

Forecasting contemporaneous aggregates with stochastic aggregation weights

Inhibitoren der AChE, BuChE und der Amyloid-β-Aggregation [Amyloid-Beta-Aggregation] vom Pyridylenhydrazon-Typ

Related objects

Reset password