An Iodide‐Mediated Anodic Amide Coupling

Abstract: The ubiquity of amide bonds, present in natural products and common pharmaceuticals renders this functional group one of the most prevalent in organic chemistry. Despite its importance and a wide variety of existing methods for its formation, the latter still can be a challenge for classical activating reagents such as chloridating agents or carbodiimides. As the spent reagents often cannot be recycled, the development of more sustainable methods is highly desirable. Herein, we report an operationally simple and mild indirect electrochemical protocol to effect the condensation of carboxylic acids with amines, forming a wide variety of carboxamides.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
An Iodide‐Mediated Anodic Amide Coupling ; day:22 ; month:08 ; year:2022 ; extent:1
Chemistry - a European journal ; (22.08.2022) (gesamt 1)

Creator
Großmann, Luca Marius
Beier, Vera
Duttenhofer, Lea
Lennartz, Laura
Opatz, Till

DOI
10.1002/chem.202201768
URN
urn:nbn:de:101:1-2022082315073613542391
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:23 AM CEST

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Associated

  • Großmann, Luca Marius
  • Beier, Vera
  • Duttenhofer, Lea
  • Lennartz, Laura
  • Opatz, Till

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