New horizons in mitochondrial contact site research

Abstract: Contact sites, areas where two organelles are held in close proximity through the action of molecular tethers, enable non-vesicular communication between compartments. Mitochondria have been center stage in the contact site field since the discovery of the first contact between mitochondria and the endoplasmic reticulum (ER) over 60 years ago. However, only now, in the last decade, has there been a burst of discoveries regarding contact site biology in general and mitochondrial contacts specifically. The number and types of characterized contacts increased dramatically, new molecular mechanisms enabling contact formation were discovered, additional unexpected functions for contacts were shown, and their roles in cellular and organismal physiology were emphasized. Here, we focus on mitochondria as we highlight the most recent developments, future goals and unresolved questions in the field.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: New horizons in mitochondrial contact site research ; volume:401 ; number:6-7 ; year:2020 ; pages:793-809 ; extent:17 ; Biological chemistry ; 401, Heft 6-7 (2020), 793-809 (gesamt 17)

Contributors, Places and Time

• Creator: Zung, Naama ; Schuldiner, Maya

Further information

• DOI: 10.1515/hsz-2020-0133
• URN: urn:nbn:de:101:1-2408061556352.044352389107
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:57 AM CEST