Biofabrication and Monitoring of a 3D Printed Skin Model for Melanoma

Abstract: There is an unmet need for in vitro cancer models that emulate the complexity of human tissues. 3D‐printed solid tumor micromodels based on decellularized extracellular matrices (dECMs) recreate the biomolecule‐rich matrix of native tissue. Herein a 3D in vitro metastatic melanoma model that is amenable for drug screening purposes and recapitulates features of both the tumor and the skin microenvironment is described. Epidermal, basement membrane, and dermal biocompatible inks are prepared by means of combined chemical, mechanical, and enzymatic processes. Bioink printability is confirmed by rheological assessment and bioprinting, and bioinks are subsequently combined with melanoma cells and dermal fibroblasts to build complex 3D melanoma models. Cells are tracked by confocal microscopy and surface‐enhanced Raman spectroscopy (SERS) mapping. Printed dECMs and cell tracking allow modeling of the initial steps of metastatic disease, and may be used to better understand melanoma cell behavior and response to drugs.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Biofabrication and Monitoring of a 3D Printed Skin Model for Melanoma ; day:11 ; month:07 ; year:2024 ; extent:13 ; Advanced healthcare materials ; (11.07.2024) (gesamt 13)

Contributors, Places and Time

• Creator: Vázquez‐Aristizabal, Paula ; Henriksen‐Lacey, Malou ; García‐Astrain, Clara ; Jimenez de Aberasturi, Dorleta ; Langer, Judith ; Epelde, Claudia ; Litti, Lucio ; Liz‐Marzán, Luis M. ; Izeta, Ander

Further information

• DOI: 10.1002/adhm.202401136
• URN: urn:nbn:de:101:1-2407121438502.608715642628
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:55 AM CEST