pH‐Responsive Aminobenzocoumarins as Fluorescent Probes for Biological Acidity

Abstract: Regulation of pH plays an essential role in orchestrating the delicate cellular machinery responsible for life as we know it. Its abnormal values are indicative of aberrant cellular behavior and associated with pathologies including cancer progression or solid tumors. Here, we report a series of bent and linear aminobenzocoumarins decorated with different substituents. We investigate their photophysical properties and demonstrate that the probes display strong pH‐responsive fluorescence “turn on” behavior in highly acidic environments, with enhancement up to 300‐fold. In combination with their low cytotoxicity, this behavior enabled their application in bioimaging of acidic lysosomes in live human cells. We believe that these molecules serve as attractive lead structures for future rational design of novel biocompatible fluorescent pH probes.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: pH‐Responsive Aminobenzocoumarins as Fluorescent Probes for Biological Acidity ; day:02 ; month:04 ; year:2024 ; extent:9 ; Chemistry - a European journal ; (02.04.2024) (gesamt 9)

Beteiligte, Orts- und Zeitangaben

• Urheber: Schniererová, Karin ; Janeková, Hana ; Joniak, Jakub ; Putala, Martin ; Štacko, Peter ; Stankovičová, Henrieta

Weitere Informationen

• DOI: 10.1002/chem.202400111
• URN: urn:nbn:de:101:1-2024040314203321866653
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 11:01 MESZ