The function of non-coding RNAs in idiopathic pulmonary fibrosis
Abstract: Non-coding ribonucleic acids (ncRNAs) are a diverse group of RNA molecules that are mostly not translated into proteins after transcription, including long non-coding RNAs (lncRNAs) with longer than 200 nucleotides non-coding transcripts and microRNAs (miRNAs) which are only 18–22 nucleotides. As families of evolutionarily conserved ncRNAs, lncRNAs activate and repress genes via a variety of mechanisms at both transcriptional and translational levels, whereas miRNAs regulate protein-coding gene expression mainly through mRNA silencing. ncRNAs are widely involved in biological functions, such as proliferation, differentiation, migration, angiogenesis, and apoptosis. Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor prognosis. The etiology of IPF is still unclear. Increasing evidence shows the close correlations between the development of IPF and aberrant expressions of ncRNAs than thought previously. In this study, we provide an overview of ncRNAs participated in pathobiology of IPF, seeking the early diagnosis biomarker and aiming for potential therapeutic applications for IPF.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The function of non-coding RNAs in idiopathic pulmonary fibrosis ; volume:16 ; number:1 ; year:2021 ; pages:481-490 ; extent:10
Open medicine ; 16, Heft 1 (2021), 481-490 (gesamt 10)
- Creator
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Zhang, Hui
Song, Miao
Guo, Jianing
Ma, Junbing
Qiu, Min
Yang, Zheng
- DOI
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10.1515/med-2021-0231
- URN
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urn:nbn:de:101:1-2022092015152656477124
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhang, Hui
- Song, Miao
- Guo, Jianing
- Ma, Junbing
- Qiu, Min
- Yang, Zheng
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