The judicious use of stereotactic ablative radiotherapy in the primary management of localized renal cell carcinoma

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Abstract: Localized renal cell carcinoma is primarily managed surgically, but this disease commonly presents in highly comorbid patients who are poor operative candidates. Less invasive techniques, such as cryoablation and radiofrequency ablation, are effective, but require percutaneous or laparoscopic access, while generally being limited to cT1a tumors without proximity to the renal pelvis or ureter. Active surveillance is another management option for small renal masses, but many patients desire treatment or are poor candidates for active surveillance. For poor surgical candidates, a growing body of evidence supports stereotactic ablative radiotherapy (SABR) as a safe and effective non-invasive treatment modality. For example, a recent multi-institution individual patient data meta-analysis of 190 patients managed with SABR estimated a 5.5% five-year cumulative incidence of local failure with one patient experiencing grade 4 toxicity, and no other grade ≥3 toxic events. Here, we discuss the recent developments in SABR for the management of localized renal cell carcinoma, highlighting key concepts of appropriate patient selection, treatment design, treatment delivery, and response assessment

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Cancers. - 15, 14 (2023) , 3672, ISSN: 2072-6694

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2023
Urheber
Barbour, Andrew B.
Kirste, Simon
Grosu, Anca-Ligia
Siva, Shankar
Louie, Alexander V.
Onishi, Hiroshi
Swaminath, Anand
Teh, Bin S.
Psutka, Sarah P.
Weg, Emily S.
Chen, Jonathan
Zeng, Jing
Gore, John L.
Hall, Evan
Liao, Jay J.
Correa, Rohann J. M.
Lo, Simon S.

DOI
10.3390/cancers15143672
URN
urn:nbn:de:bsz:25-freidok-2382043
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
25.03.2025, 13:43 MEZ

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Beteiligte

  • Barbour, Andrew B.
  • Kirste, Simon
  • Grosu, Anca-Ligia
  • Siva, Shankar
  • Louie, Alexander V.
  • Onishi, Hiroshi
  • Swaminath, Anand
  • Teh, Bin S.
  • Psutka, Sarah P.
  • Weg, Emily S.
  • Chen, Jonathan
  • Zeng, Jing
  • Gore, John L.
  • Hall, Evan
  • Liao, Jay J.
  • Correa, Rohann J. M.
  • Lo, Simon S.
  • Universität

Entstanden

  • 2023

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