All‐ Trans ‐Retinoic Acid‐Adjuvanted mRNA Vaccine Induces Mucosal Anti‐Tumor Immune Responses for Treating Colorectal Cancer
Abstract: Messenger RNA (mRNA) cancer vaccines are a new class of immunotherapies that can activate the immune system to recognize and destroy cancer cells. However, their effectiveness in treating colorectal cancer located on the mucosal surface of the gut is limited due to the insufficient activation of mucosal immune response and inadequate infiltration of cytotoxic T cells into tumors. To address this issue, a new mRNA cancer vaccine is developed that can stimulate mucosal immune responses in the gut by co‐delivering all‐trans‐retinoic acid (ATRA) and mRNA using lipid nanoparticle (LNP). The incorporation of ATRA has not only improved the mRNA transfection efficiency of LNP but also induced high expression of gut‐homing receptors on vaccine‐activated T cells. Additionally, the use of LNP improves the aqueous solubility of ATRA, eliminating the need for toxic solvents to administer ATRA. Upon intramuscular injections, ATRA‐adjuvanted mRNA‐LNP significantly increase the infiltration of antigen‐specific, cytotoxic T cells in the lamina propria of the intestine, mesenteric lymph nodes, and orthotopic colorectal tumors, resulting in significantly improved tumor inhibition and prolonged animal survival compared to conventional mRNA‐LNP without ATRA. Overall, this study provides a promising approach for improving the therapeutic efficacy of mRNA cancer vaccines against colorectal cancer.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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All‐ Trans ‐Retinoic Acid‐Adjuvanted mRNA Vaccine Induces Mucosal Anti‐Tumor Immune Responses for Treating Colorectal Cancer ; day:25 ; month:03 ; year:2024 ; extent:14
Advanced science ; (25.03.2024) (gesamt 14)
- Creator
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Li, Wei
Li, Yijia
Li, Jingjiao
Meng, Junli
Jiang, Ziqiong
Yang, Chen
Wen, Yixing
Liu, Shuai
Cheng, Xingdi
Mi, Shiwei
zhao, Yuanyuan
Miao, Lei
Lu, Xueguang
- DOI
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10.1002/advs.202309770
- URN
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urn:nbn:de:101:1-2024032613324748615656
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:58 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Li, Wei
- Li, Yijia
- Li, Jingjiao
- Meng, Junli
- Jiang, Ziqiong
- Yang, Chen
- Wen, Yixing
- Liu, Shuai
- Cheng, Xingdi
- Mi, Shiwei
- zhao, Yuanyuan
- Miao, Lei
- Lu, Xueguang
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