C−F Bond Insertion: An Emerging Strategy for Constructing Fluorinated Molecules
Abstract: C−F Insertion reactions, where an organic fragment formally inserts into a carbon–fluorine bond in a substrate, are highly attractive, yet largely unexplored, methods to prepare valuable fluorinated molecules. The inherent strength of C−F bonds and the resulting need for a large thermodynamic driving force to initiate C−F cleavage often leads to sequestering of the released fluoride in an unreactive by‐product. Recently, however, several groups have succeeded in overcoming this challenge, opening up the study of C−F insertion as an efficient and highly atom‐economical approach to prepare fluorinated compounds. In this article, the recent breakthroughs are discussed focusing on the key conceptual advances that allowed for both C−F bond cleavage and subsequent incorporation of the released fluoride into the product.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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C−F Bond Insertion: An Emerging Strategy for Constructing Fluorinated Molecules ; day:21 ; month:02 ; year:2024 ; extent:9
Chemistry - a European journal ; (21.02.2024) (gesamt 9)
- Creator
- DOI
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10.1002/chem.202304229
- URN
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urn:nbn:de:101:1-2024022214462417406752
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:53 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Garg, Arushi
- Haswell, Alex
- Hopkinson, Matthew
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