Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family
Abstract: Mannose-binding lectin 2 (MBL2) is a serine protease which is believed to be an important factor in the inherited immune system. In this article, we present a coronavirus disease 2019 (COVID-19) family of five patients: a 56-year-old father, a 51-year-old mother, two sons aged 23 and 21 years, and a 15-year-old daughter. According to the results of MBL2 rs1800450 variant analysis performed, the father had homozygous mutant, the mother had homozygous normal, and the three children had heterozygous mutant genotype. When we compared the clinical parameters and genotypes, MBL2 gene polymorphism plays a very important role in COVID-19 susceptibility and severe disease. The family, which makes up our study, is the proof of this situation, and it contains important implications for host factors and COVID-19.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family ; day:25 ; month:02 ; year:2022
Global medical genetics ; (25.02.2022)
- Contributor
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Tukek, Tufan
Pehlivan, Sacide
Oyaci, Yasemin
Isoglu-Alkac, Ummuhan
- DOI
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10.1055/s-0042-1743258
- URN
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urn:nbn:de:101:1-2022042111293817829259
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:30 AM CEST
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Associated
- Tukek, Tufan
- Pehlivan, Sacide
- Oyaci, Yasemin
- Isoglu-Alkac, Ummuhan
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Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema
Accelerated wound healing and reduced scar formation induced by D-mannose: a possible role of mannose binding lectin
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