CHIP and atherothrombotic risk
Haematopoiesis is the process of blood production, essential for the continued supply of immune cells and red blood cells. However, the proliferative nature of haematopoietic stem cell (HSCs) renders them susceptible to developing somatic mutations. HSCs carrying a mutation can gain a selective advantage compared to normal HSCs and result in haematological disorders. One such disorder is termed clonal haematopoiesis of indeterminate potential (CHIP), a pre-malignant state associated with ageing, where the mutant HSCs are responsible for producing a small portion of the mature immune cells in the circulation and subsequently in tissues. People with CHIP have been shown to have an increased risk of mortality due to cardiovascular disease (CVD). Why this occurs is under rigorous investigation, but the majority of the studies to date suggest increased atherosclerosis is due to heightened inflammatory cytokine release from mutant lesional macrophages. However, given CHIP is driven by several mutations, other haematopoietic lineages can be altered to promote CVD. In this review we explore the relationship between mutations in genes causing CHIP and atherothrombotic disorders, along with potential mechanisms of enhanced clonal outgrowth and potential therapies and strategies to slow CHIP progression.
- Alternative title
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State-of-the-art Mini Review
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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CHIP and atherothrombotic risk ; day:20 ; month:04 ; year:2022
Thrombosis and haemostasis ; (20.04.2022)
- Contributor
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Murphy, Andrew James
Dragoljevic, Dragana
Natarajan, Pradeep
Wang, Nan
- DOI
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10.1055/a-1830-2147
- URN
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urn:nbn:de:101:1-2022060911160705313494
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:31 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Murphy, Andrew James
- Dragoljevic, Dragana
- Natarajan, Pradeep
- Wang, Nan
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