Functional Ultrasound Speckle Decorrelation‐Based Velocimetry of the Brain

Abstract: A high‐speed, contrast‐free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first‐order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring the blood flow velocity changes during whisker stimulation in awake mice. Compared to existing Power‐Doppler‐ and Color‐Doppler‐based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high‐frequency noise.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Functional Ultrasound Speckle Decorrelation‐Based Velocimetry of the Brain ; volume:7 ; number:18 ; year:2020 ; extent:12
Advanced science ; 7, Heft 18 (2020) (gesamt 12)

Creator
Tang, Jianbo
Postnov, Dmitry D.
Kilic, Kivilcim
Erdener, Sefik Evren
Lee, Blaire
Giblin, John T.
Szabo, Thomas L.
Boas, David A.

DOI
10.1002/advs.202001044
URN
urn:nbn:de:101:1-2022062411081788935958
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:21 AM CEST

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Associated

  • Tang, Jianbo
  • Postnov, Dmitry D.
  • Kilic, Kivilcim
  • Erdener, Sefik Evren
  • Lee, Blaire
  • Giblin, John T.
  • Szabo, Thomas L.
  • Boas, David A.

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