Model Order Reduction (MOR) of Function‐Perfusion‐Growth Simulation in the Human Fatty Liver via Artificial Neural Network (ANN)

Abstract: Numerical modeling of biological systems has become an important assistance for understanding and predicting hepatic diseases like non‐alcoholic fatty liver disease (NAFLD) or the detoxification of drugs and toxines by the liver. We developed a model for the simulation of hepatic function‐perfusion processes using a multiscale and multiphase approach. Here, the liver lobules are described using a homogenization approach with a coupled set of partial differential equations (PDE) based on the Theory of Porous Media (TPM) to describe the coupled blood transport and tissue deformation. For the description of metabolic processes on cellular scale ordinary differential equations (ODE) are used. For many practical and clinical applications, e.g. optimization procedures or uncertainty quantification, a fast but reliable computation is required. Thus, we use a non‐linear model order reduction (MOR) based on an artificial neural network (ANN) for the prediction of simulation results. The practicability of this approach is shown in a comparison between the high fidelity numerical simulation of a NAFLD and the predicted results by the ANN.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Model Order Reduction (MOR) of Function‐Perfusion‐Growth Simulation in the Human Fatty Liver via Artificial Neural Network (ANN) ; volume:19 ; number:1 ; year:2019 ; extent:2
Proceedings in applied mathematics and mechanics ; 19, Heft 1 (2019) (gesamt 2)

Creator
Lambers, Lena
Ricken, Tim
König, Matthias

DOI
10.1002/pamm.201900429
URN
urn:nbn:de:101:1-2022072208112138545212
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:22 AM CEST

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Associated

  • Lambers, Lena
  • Ricken, Tim
  • König, Matthias

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