Kinetic Resolution of Racemic Primary Amines Using Geobacillus stearothermophilus Amine Dehydrogenase Variant
Abstract: A NADH‐dependent engineered amine dehydrogenase from Geobacillus stearothermophilus (LE‐AmDH‐v1) was applied together with a NADH‐oxidase from Streptococcus mutans (NOx) for the kinetic resolution of pharmaceutically relevant racemic α‐chiral primary amines. The reaction conditions (e. g., pH, temperature, type of buffer) were optimised to yield S‐configured amines with up to >99 % ee.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Kinetic Resolution of Racemic Primary Amines Using Geobacillus stearothermophilus Amine Dehydrogenase Variant ; volume:12 ; number:8 ; year:2020 ; pages:2184-2188 ; extent:5
ChemCatChem ; 12, Heft 8 (2020), 2184-2188 (gesamt 5)
- Creator
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Tseliou, Vasilis
Knaus, Tanja
Vilím, Jan
Masman, Marcelo F.
Mutti, Francesco G.
- DOI
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10.1002/cctc.201902085
- URN
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urn:nbn:de:101:1-2022070311525494421849
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:23 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Tseliou, Vasilis
- Knaus, Tanja
- Vilím, Jan
- Masman, Marcelo F.
- Mutti, Francesco G.
Other Objects (12)
Kinetic Resolution of Primary Amines through Chiral Phosphoric Acid Catalysis
Synthesis of Chiral Amines via a Bi‐Enzymatic Cascade Using an Ene‐Reductase and Amine Dehydrogenase
Structure and Mutation of the Native Amine Dehydrogenase MATOUAmDH2
High coenzyme affinity chimeric amine dehydrogenase based on domain engineering
Über Azomethine und Benzal-bis-amine einiger heterocyklischer Amine
Preparation of Amines
Geschichte der Amine.
Festphasenmikroextraktion aromatischer Amine
Nitrite und Amine
Gesichte der Amine.
Lehrgang 17: Amine
VIII. Kapitel. Amine.
Kinetic Resolution of Primary Amines through Chiral Phosphoric Acid Catalysis
Synthesis of Chiral Amines via a Bi‐Enzymatic Cascade Using an Ene‐Reductase and Amine Dehydrogenase
Structure and Mutation of the Native Amine Dehydrogenase MATOUAmDH2
High coenzyme affinity chimeric amine dehydrogenase based on domain engineering
Über Azomethine und Benzal-bis-amine einiger heterocyklischer Amine
Preparation of Amines
Geschichte der Amine.
Festphasenmikroextraktion aromatischer Amine
Nitrite und Amine
Gesichte der Amine.
Lehrgang 17: Amine
VIII. Kapitel. Amine.
Kinetic Resolution of Primary Amines through Chiral Phosphoric Acid Catalysis
Synthesis of Chiral Amines via a Bi‐Enzymatic Cascade Using an Ene‐Reductase and Amine Dehydrogenase
Structure and Mutation of the Native Amine Dehydrogenase MATOUAmDH2
High coenzyme affinity chimeric amine dehydrogenase based on domain engineering
Über Azomethine und Benzal-bis-amine einiger heterocyklischer Amine
Preparation of Amines
Geschichte der Amine.
Festphasenmikroextraktion aromatischer Amine
Nitrite und Amine
Gesichte der Amine.
Lehrgang 17: Amine