Genetic susceptibility to high myopia in Han Chinese population
Abstract: High myopia is a common ocular genetic disease in the world. The study sought to investigate the effect of the Insulin-like growth factor-1 (IGF-1) and Matrix metalloproteinase-9 (MMP-9) genes polymorphisms on high myopia in a Han population of China. This study recruited 216 unrelated Han Chinese subjects, including 103 cases with high myopia and 113 controls. Four tagging single nucleotide polymorphisms (SNPs) of IGF-1 and MMP-9 genes were genotyped using the Sequenom MassARRAY method. The chi-square test showed that the family history was significantly correlated with myopia. The SNP genotypes were all in Hardy–Weinberg equilibrium (P > 0.05). Among the four SNPs, there were statistically significant differences in the genotype and allele frequencies of rs2236416 between the groups (P = 0.024). The significant associations of rs2236416 between cases and controls also appeared after Bonferroni multiple correction (P = 0.024). Then, there were significant differences in the genotypes dominant model and codominant model of rs2236416 between groups (P = 0.007 and P = 0.004, respectively). rs5742632 showed a significant difference between the cases and the controls in the recessive model (P = 0.037). Our findings indicated that rs2236416 of MMP-9 was associated with myopia in the population. The result suggested MMP-9 gene locus may play a role in myopia.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Genetic susceptibility to high myopia in Han Chinese population ; volume:17 ; number:1 ; year:2022 ; pages:512-516 ; extent:5
Open life sciences ; 17, Heft 1 (2022), 512-516 (gesamt 5)
- Urheber
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Li, Yufei
Zhang, Yong
Zhang, Ping
Gao, Lei
Ma, Qingyue
Li, Jin
Wang, Shengxia
Liu, Bing
Wang, Xinye
Meng, Chao
- DOI
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10.1515/biol-2022-0055
- URN
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urn:nbn:de:101:1-2022071515441003418008
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Li, Yufei
- Zhang, Yong
- Zhang, Ping
- Gao, Lei
- Ma, Qingyue
- Li, Jin
- Wang, Shengxia
- Liu, Bing
- Wang, Xinye
- Meng, Chao
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