HFIP Mediates a Direct C−C Coupling between Michael Acceptors and Eschenmoser's salt
Abstract: A direct C−C coupling process that merges Michael acceptors and Eschenmoser's salt is presented. Although reminiscent of the Morita–Baylis–Hillman reaction, this process requires no Lewis base catalyst. The underlying mechanism was unveiled by a combination of kinetic, isotopic labelling experiments as well as computational investigations, which showcased the critical role of HFIP as a superior mediator for proton‐transfer events as well as the decisive role of the halide counterion.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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HFIP Mediates a Direct C−C Coupling between Michael Acceptors and Eschenmoser's salt ; day:03 ; month:02 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (03.02.2022) (gesamt 1)
- Creator
- DOI
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10.1002/anie.202109933
- URN
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urn:nbn:de:101:1-2022020414150841045375
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lemmerer, Miran
- Riomet, Margaux
- Meyrelles, Ricardo
- Maryasin, Boris
- González, Leticia
- Maulide, Nuno
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