A Synthetic Dynamic Polyvinyl Alcohol Photoresin for Fast Volumetric Bioprinting of Functional Ultrasoft Hydrogel Constructs
Abstract: Tomographic volumetric bioprinting (VBP) enables fast photofabrication of cell‐laden hydrogel constructs in one step, addressing the limitations of conventional layer‐by‐layer additive manufacturing. However, existing biomaterials that fulfill the physicochemical requirements of VBP are limited to gelatin‐based photoresins of high polymer concentrations. The printed microenvironments are predominantly static and stiff, lacking sufficient capacity to support 3D cell growth. Here a dynamic resin based on thiol–ene photo‐clickable polyvinyl alcohol (PVA) and thermo‐sensitive sacrificial gelatin for fast VBP of functional ultrasoft cell‐laden hydrogel constructs within 7–15 s is reported. Using gelatin allows VBP of permissive hydrogels with low PVA contents of 1.5%, providing a stress‐relaxing environment for fast cell spreading, 3D osteogenic differentiation of embedded human mesenchymal stem cells and matrix mineralization. Additionally, site‐specific immobilization of molecules‐of‐interest inside a PVA hydrogel is achieved by 3D tomographic thiol–ene photopatterning. This technique may enable spatiotemporal control of cell‐material interactions and guides in vitro tissue formation using programmed cell‐friendly light. Altogether, this study introduces a synthetic dynamic photoresin enabling fast VBP of functional ultrasoft hydrogel constructs with well‐defined physicochemical properties and high efficiency.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
A Synthetic Dynamic Polyvinyl Alcohol Photoresin for Fast Volumetric Bioprinting of Functional Ultrasoft Hydrogel Constructs ; day:12 ; month:02 ; year:2023 ; extent:11
Advanced functional materials ; (12.02.2023) (gesamt 11)
- Creator
-
Qiu, Wanwan
Gehlen, Jenny
Bernero, Margherita
Gehre, Christian
Schädli, Gian Nutal
Müller, Ralph
Qin, Xiao‐Hua
- DOI
-
10.1002/adfm.202214393
- URN
-
urn:nbn:de:101:1-2023021314230714149083
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:49 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Qiu, Wanwan
- Gehlen, Jenny
- Bernero, Margherita
- Gehre, Christian
- Schädli, Gian Nutal
- Müller, Ralph
- Qin, Xiao‐Hua
Other Objects (12)
Volumetric Bioprinting of Complex Living‐Tissue Constructs within Seconds
Bioprinting of skin constructs for wound healing
Engineering zonal cartilage through bioprinting collagen type II hydrogel constructs with biomimetic chondrocyte density gradient
Mini-review: advances in 3D bioprinting of vascularized constructs
Three-dimensional bioprinting of volumetric tissues and organs
Optimized Photoclick (Bio)Resins for Fast Volumetric Bioprinting
Tissue Engineered 3D Constructs for Volumetric Muscle Loss
Bioprinting of Stable Bionic Interfaces Using Piezoresistive Hydrogel Organoelectronics
3D bioprinting of hydrogel/ceramic composites with hierarchical porosity
Fiber-reinforced polyvinyl alcohol hydrogel via in situ fiber formation
3D Bioprinting of Macroporous Materials Based on Entangled Hydrogel Microstrands
3D Bioprinting of Multicellular Stem Cell‐Derived Constructs to Model Pancreatic Cell Differentiation
Volumetric Bioprinting of Complex Living‐Tissue Constructs within Seconds
Bioprinting of skin constructs for wound healing
Engineering zonal cartilage through bioprinting collagen type II hydrogel constructs with biomimetic chondrocyte density gradient
Mini-review: advances in 3D bioprinting of vascularized constructs
Three-dimensional bioprinting of volumetric tissues and organs
Optimized Photoclick (Bio)Resins for Fast Volumetric Bioprinting
Tissue Engineered 3D Constructs for Volumetric Muscle Loss
Bioprinting of Stable Bionic Interfaces Using Piezoresistive Hydrogel Organoelectronics
3D bioprinting of hydrogel/ceramic composites with hierarchical porosity
Fiber-reinforced polyvinyl alcohol hydrogel via in situ fiber formation
3D Bioprinting of Macroporous Materials Based on Entangled Hydrogel Microstrands
3D Bioprinting of Multicellular Stem Cell‐Derived Constructs to Model Pancreatic Cell Differentiation
Volumetric Bioprinting of Complex Living‐Tissue Constructs within Seconds
Bioprinting of skin constructs for wound healing
Engineering zonal cartilage through bioprinting collagen type II hydrogel constructs with biomimetic chondrocyte density gradient
Mini-review: advances in 3D bioprinting of vascularized constructs
Three-dimensional bioprinting of volumetric tissues and organs
Optimized Photoclick (Bio)Resins for Fast Volumetric Bioprinting
Tissue Engineered 3D Constructs for Volumetric Muscle Loss
Bioprinting of Stable Bionic Interfaces Using Piezoresistive Hydrogel Organoelectronics
3D bioprinting of hydrogel/ceramic composites with hierarchical porosity
Fiber-reinforced polyvinyl alcohol hydrogel via in situ fiber formation
3D Bioprinting of Macroporous Materials Based on Entangled Hydrogel Microstrands