Photochemical Asymmetric Nickel‐Catalyzed Acyl Cross‐Coupling

Abstract: Photochemical enantioselective nickel‐catalyzed cross‐coupling reactions are difficult to implement. We report a visible‐light‐mediated strategy that successfully couples symmetrical anhydrides and 4‐alkyl dihydropyridines (DHPs) to afford enantioenriched α‐substituted ketones under mild conditions. The chemistry does not require exogenous photocatalysts. It is triggered by the direct excitation of DHPs, which act as a radical source and as a reductant, facilitating the turnover of the chiral catalytic nickel complex.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Photochemical Asymmetric Nickel‐Catalyzed Acyl Cross‐Coupling ; volume:58 ; number:47 ; year:2019 ; pages:16854-16858 ; extent:5
Angewandte Chemie / International edition. International edition ; 58, Heft 47 (2019), 16854-16858 (gesamt 5)

Creator
Gandolfo, Eugenio
Tang, Xinjun
Raha Roy, Sudipta
Melchiorre, Paolo

DOI
10.1002/anie.201910168
URN
urn:nbn:de:101:1-2022071211050144390802
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:25 AM CEST

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Associated

  • Gandolfo, Eugenio
  • Tang, Xinjun
  • Raha Roy, Sudipta
  • Melchiorre, Paolo

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