Low level lysosomal membrane permeabilization for limited release and sub‐lethal functions of cathepsin proteases in the cytosol and nucleus
Abstract: For a long time, lysosomes were purely seen as organelles in charge of garbage disposal within the cell. They destroy any cargo delivered into their lumen with a plethora of highly potent hydrolytic enzymes, including various proteases. In case of damage to their limiting membranes, the lysosomes release their soluble content with detrimental outcomes for the cell. In recent years however, this view of the lysosome changed towards acknowledging it as a platform for integration of manifold intra- and extracellular signals. Even impaired lysosomal membrane integrity is no longer considered to be a one-way street to cell death. Increasing evidence suggests that lysosomal enzymes, mainly cathepsin proteases, can be released in a spatially and temporarily restricted manner that is compatible with cellular survival. This way, cathepsins can act in the cytosol and the nucleus, where they affect important cellular processes such as cell division. Here, we review this evidence and discuss the routes and molecular mechanisms by which the cathepsins may reach their unusual destination
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
FEBS open bio. - 12, 4 (2022) , 694-707, ISSN: 2211-5463
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2022
- Urheber
- DOI
-
10.1002/2211-5463.13385
- URN
-
urn:nbn:de:bsz:25-freidok-2253629
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:56 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Reinheckel, Thomas
- Tholen, Martina
- Universität
Entstanden
- 2022
Ähnliche Objekte (12)
A system view on murine breast cancer progression and the impact of the lysosomal proteases cathepsin B and cathepsin Z
Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
Contribution of cathepsin proteases to cellular protein homeostasis
Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase
Pathogenic functions of the lysosomal protease cathepsin B in murine invasive breast cancer
The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases
Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells
Lethal Affairs. Love has never been more lethal
Endosomal lysosomal proteases in epithelial to mesenchymal transition (EMT) and invasion of normal and malignant mammary epithelium
A system view on murine breast cancer progression and the impact of the lysosomal proteases cathepsin B and cathepsin Z
Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
Contribution of cathepsin proteases to cellular protein homeostasis
Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase
Pathogenic functions of the lysosomal protease cathepsin B in murine invasive breast cancer
The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases
Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells
Lethal Affairs. Love has never been more lethal
Endosomal lysosomal proteases in epithelial to mesenchymal transition (EMT) and invasion of normal and malignant mammary epithelium
A system view on murine breast cancer progression and the impact of the lysosomal proteases cathepsin B and cathepsin Z
Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
Contribution of cathepsin proteases to cellular protein homeostasis
Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase
Pathogenic functions of the lysosomal protease cathepsin B in murine invasive breast cancer
The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases
Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells
Lethal Affairs. Love has never been more lethal