Self‐Assembled Peptide‐Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells

Lung cancer cells resistant to radiotherapy present a significant clinical challenge. Stable telomeric structures, maintained by the TRF2 protein, play a critical role in protecting cells from ionizing radiation. Reduced TRF2 expression increases DNA damage and radiosensitivity. We designed a self‐assembling system utilizing ultra‐small luminescent gold nanoclusters (AuNCs) with radiosensitizing properties, combined with siRNA targeting TRF2. The system forms ≈100 nm non‐spherical structures with AuNCs enriched in the outer layer, exhibiting a 17.6‐fold enhancement in red photoluminescence due to aggregation‐induced effects. This nanoplatform efficiently penetrates lung cancer cells, reducing TRF2 expression by 50%. Under 5 Gy radiotherapy, cells treated with this system show a 1.5‐fold radiosensitivity increase from AuNCs and a 2.3‐fold reduction in clonogenic survival due to telomere deprotection. The AuNC‐siRNATRF2 system combines enhanced optical properties with biological functionality, offering a promising approach to augment radiotherapy efficacy by disrupting telomeric protective mechanisms in cancer cells.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Self‐Assembled Peptide‐Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells ; day:16 ; month:12 ; year:2024 ; extent:14 ; Small science ; (16.12.2024) (gesamt 14)

Contributors, Places and Time

• Creator: Moro, Sean ; Omrani, Mohammed ; Erbek, Sule ; Jourdan, Muriel ; Vandekerckhove, Catharina I. ; Nogier, Cyril ; Vanwonterghem, Laetitia ; Molina, Marie‐Carmen ; Bernadó, Pau ; Thureau, Aurélien ; Coll, Jean‐Luc ; Renaudet, Olivier ; Le Guével, Xavier ; Faure, Virginie

Further information

• DOI: 10.1002/smsc.202400156
• URN: urn:nbn:de:101:1-2412171319136.978958619406
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:24 AM CEST