Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non‐specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery of a synthetic hydrogel material with biocompatible gelation that can efficiently cover irregular tissue surfaces provides an effective approach for targeted drug delivery at the gastrointestinal (GI) tract. An ideal integration of synthetic material with intestinal epithelium entails an integrated and preferable chemically bonded interface between the hydrogel and mucosal surface. In this study, a photo‐triggered coupling reaction is leveraged as the crosslinking platform to develop a mucosal‐adhesive hydrogel, which is compatible with endoscope‐directed drug delivery for UC treatment. The results demonstrated superior spatiotemporal specificity and drug pharmacokinetics with this delivery system in vivo. Delivery of different drugs with the hydrogel leads to greatly enhanced therapeutic efficacy and significantly reduced systemic drug exposure with rat colitis models. The study presents a strategy for targeted and persistent drug delivery for UC treatment.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel ; day:03 ; month:02 ; year:2025 ; extent:12
Advanced science ; (03.02.2025) (gesamt 12)
- Urheber
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Wu, Wen
Zhang, Jian
Qu, Xiao
Chen, Ting
Li, Jinming
Yang, Yongzhi
Chen, Lifeng
Hoover, Alex
Guo, Fanying
Kong, Cheng
Bao, Bingkun
Lin, Qiuning
Zhou, Mengxin
Zhu, Linyong
Wu, Xiaoyang
Ma, Yanlei
- DOI
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10.1002/advs.202404836
- URN
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urn:nbn:de:101:1-2502041311347.111170147914
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:21 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Wu, Wen
- Zhang, Jian
- Qu, Xiao
- Chen, Ting
- Li, Jinming
- Yang, Yongzhi
- Chen, Lifeng
- Hoover, Alex
- Guo, Fanying
- Kong, Cheng
- Bao, Bingkun
- Lin, Qiuning
- Zhou, Mengxin
- Zhu, Linyong
- Wu, Xiaoyang
- Ma, Yanlei
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