Selective Aptamer‐Based Control of Intraneuronal Signaling †

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Abstract: Cellular behavior is orchestrated by the complex interactions of a myriad of intracellular signal transduction pathways. To understand and investigate the role of individual components in such signaling networks, the availability of specific inhibitors is of paramount importance. We report the generation and validation of a novel variant of an RNA aptamer that selectively inhibits the mitogen‐activated kinase pathway in neurons. We demonstrate that the aptamer retains function under intracellular conditions and that application of the aptamer through the patch‐clamp pipette efficiently inhibits mitogen‐activated kinase‐dependent synaptic plasticity. This approach introduces synthetic aptamers as generic tools, readily applicable to inhibit different components of intraneuronal signaling networks with utmost specificity.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Selective Aptamer‐Based Control of Intraneuronal Signaling † ; volume:127 ; number:18 ; year:2015 ; pages:5459-5463 ; extent:5
Angewandte Chemie ; 127, Heft 18 (2015), 5459-5463 (gesamt 5)

Creator: Lennarz, Sabine
Alich, Therese Christine
Kelly, Tony
Blind, Michael
Beck, Heinz
Mayer, Günter

DOI: 10.1002/ange.201409597

URN: urn:nbn:de:101:1-2022112807262688857150

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:34 AM CEST

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Associated

Lennarz, Sabine
Alich, Therese Christine
Kelly, Tony
Blind, Michael
Beck, Heinz
Mayer, Günter

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