Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer

Abstract: Adriamycin (ADR) is an important chemotherapy agent in many advanced cancers, but the emergence of drug resistance during treatment is a major limitation to its successful use. Recent studies have suggested that drug-resistant cells become less fit and their growth could be inhibited by parental cells without cytotoxic treatment. In this study, we examined the fitness differences between HeLa and HeLa/ADR cells. Compared with the parental cell line, HeLa/ADR cells showed significantly lower growth rates, both in vitro and in vivo. There was no difference in the apoptosis rate between them, but G1 arrest and reduced DNA synthesis were found in HeLa/ADR cells. Further study indicated that HeLa/ADR cells failed to compete for space and nutrition against parental cells in vivo. Taken together, we demonstrate that HeLa/ADR cells are less fit and their growth can be inhibited by parental cells in the absence of ADR; therefore, the maintenance of a certain amount of ADR-sensitive cells during treatment may facilitate the control of the development of ADR resistance.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer ; volume:16 ; number:1 ; year:2021 ; pages:53-60 ; extent:8
Open life sciences ; 16, Heft 1 (2021), 53-60 (gesamt 8)

Urheber
Qi, Min
Xie, Lijuan
Duan, Guihua

DOI
10.1515/biol-2021-0004
URN
urn:nbn:de:101:1-2022091914582148927200
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:25 MESZ

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Beteiligte

  • Qi, Min
  • Xie, Lijuan
  • Duan, Guihua

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