The Roles of Innate Immune Cells in Atopic Dermatitis

Abstract: Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by recurrent eczematous lesions and severe pruritus. The economic burden and time penalty caused by the relapse of AD reduce patients’ life quality. Summary: AD has complex pathogenesis, including genetic disorders, epidermal barrier dysfunction, abnormal immune responses, microbial dysbiosis of the skin, and environmental factors. Recently, the role of innate immune cells in AD has attracted considerable attention. This review highlighted recent findings on innate immune cells in the onset and progression of AD. Key Messages: Innate immune cells play essential roles in the pathogenesis of AD and enough attention should be given for treating AD from the perspective of innate immunity in clinics.
AD is a chronic inflammatory skin disease closely associated with host immune system dysfunction, manifested by compromised skin barrier. Innate immune cells present variations in quantity and function, contributing to the pathogenesis of AD via various pathways. Additionally, innate immune cells can interact with adaptive immune cells, further complicating the regulatory network. Moreover, some innate immune cells contribute to induce itching. This review describes the functions of innate immune cells in the onset and progression of AD.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: The Roles of Innate Immune Cells in Atopic Dermatitis ; volume:16 ; number:1 ; year:2024 ; pages:385-396 ; extent:12 ; Journal of innate immunity ; 16, Heft 1 (2024), 385-396 (gesamt 12)

Contributors, Places and Time

• Creator: Pan, Yuke ; Wang, Youyi ; Xu, Meinian ; Zhong, Meizhen ; Peng, Xiaoming ; Zeng, Kang ; Huang, Xiaowen

Further information

• DOI: 10.1159/000539534
• URN: urn:nbn:de:101:1-2412260126215.290626060712
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:29 AM CEST