Coenzyme A‐Conjugated Cinnamic Acids – Enzymatic Synthesis of a CoA‐Ester Library and Application in Biocatalytic Cascades to Vanillin Derivatives

Abstract: We present a bioorthogonal method for the ligation of coenzyme A (CoA) with cinnamic acids. The reaction, which is the initial step in the biosynthesis of a multitude of bioactive secondary metabolites, is catalyzed by a promiscuous plant ligase and yields CoA conjugates with different functionalization in high purity and without formation of by‐products. Its applicability in biosynthetic cascades is shown for the direct transformation of cinnamic acids into natural benzaldehydes (like vanillin) or artificial derivatives (e. g. ethylvanillin).

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Coenzyme A‐Conjugated Cinnamic Acids – Enzymatic Synthesis of a CoA‐Ester Library and Application in Biocatalytic Cascades to Vanillin Derivatives ; volume:361 ; number:23 ; year:2019 ; pages:5346-5350 ; extent:5 ; Advanced synthesis & catalysis ; 361, Heft 23 (2019), 5346-5350 (gesamt 5)

Contributors, Places and Time

• Creator: Dippe, Martin ; Bauer, Anne‐Katrin ; Porzel, Andrea ; Funke, Evelyn ; Müller, Anna O. ; Schmidt, Jürgen ; Beier, Maria ; Wessjohann, Ludger

Further information

• DOI: 10.1002/adsc.201900892
• URN: urn:nbn:de:101:1-2022072413205231463381
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:35 AM CEST