Functional ribosome biogenesis is a prerequisite for p53 destabilization: impact of chemotherapy on nucleolar functions and RNA metabolism
Abstract: The production and processing of ribosomal RNA is a complex and well-coordinated nucleolar process for ribosome biogenesis. Progress in understanding nucleolar structure and function has lead to the unexpected discovery of the nucleolus as a highly sensitive sensor of cellular stress and an important regulator of the tumor suppressor p53. Inhibition of ribosomal RNA metabolism has been shown to activate a signaling pathway for p53 induction. This review elucidates the potential of classical and recently developed chemotherapeutic drugs to stabilize p53 by inhibiting nucleolar functions.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Functional ribosome biogenesis is a prerequisite for p53 destabilization: impact of chemotherapy on nucleolar functions and RNA metabolism ; volume:394 ; number:9 ; year:2013 ; pages:1133-1143
Biological chemistry ; 394, Heft 9 (2013), 1133-1143
- Creator
-
Burger, Kaspar
Eick, Dirk
- DOI
-
10.1515/hsz-2013-0153
- URN
-
urn:nbn:de:101:1-2408051639578.608074978618
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:53 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Burger, Kaspar
- Eick, Dirk
Other Objects (12)
Nucleolin: a nucleolar rna-binding protein involved in ribosome biogenesis
The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation
FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex
Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis
USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Commuting to work: Nucleolar long non-coding RNA control ribosome biogenesis from near and far
The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei
Inhibiting eukaryotic ribosome biogenesis
The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis
The nucleolus and ribosome biogenesis
Evolution of the holozoan ribosome biogenesis regulon
Ribosome biogenesis factors—from names to functions
Nucleolin: a nucleolar rna-binding protein involved in ribosome biogenesis
The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation
FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex
Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis
USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Commuting to work: Nucleolar long non-coding RNA control ribosome biogenesis from near and far
The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei
Inhibiting eukaryotic ribosome biogenesis
The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis
The nucleolus and ribosome biogenesis
Evolution of the holozoan ribosome biogenesis regulon
Ribosome biogenesis factors—from names to functions
Nucleolin: a nucleolar rna-binding protein involved in ribosome biogenesis
The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation
FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex
Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis
USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Commuting to work: Nucleolar long non-coding RNA control ribosome biogenesis from near and far
The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei
Inhibiting eukaryotic ribosome biogenesis
The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis
The nucleolus and ribosome biogenesis
Evolution of the holozoan ribosome biogenesis regulon