Nucleosome organization and chromatin dynamics in telomeres
Abstract: Telomeres are DNA-protein complexes located at the ends of linear eukaryotic chromosomes, and are essential for chromosome stability and maintenance. In most organisms, telomeres consist of tandemly repeated sequences of guanine-clusters. In higher eukaryotes, most of the telomeric repeat regions are tightly packaged into nucleosomes, even though telomeric repeats act as nucleosome-disfavoring sequences. Although telomeres were considered to be condensed heterochromatin structures, recent studies revealed that the chromatin structures in telomeres are actually dynamic. The dynamic properties of telomeric chromatin are considered to be important for the structural changes between the euchromatic and heterochromatic states during the cell cycle and in cellular differentiation. We propose that the nucleosome-disfavoring property of telomeric repeats is a crucial determinant for the lability of telomeric nucleosomes, and provides a platform for chromatin dynamics in telomeres. Furthermore, we discuss the influences of telomeric components on the nucleosome organization and chromatin dynamics in telomeres.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Nucleosome organization and chromatin dynamics in telomeres ; volume:6 ; number:1 ; year:2015 ; pages:67-75 ; extent:9
Biomolecular concepts ; 6, Heft 1 (2015), 67-75 (gesamt 9)
- Creator
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Ichikawa, Yuichi
Nishimura, Yoshifumi
Kurumizaka, Hitoshi
Shimizu, Mitsuhiro
- DOI
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10.1515/bmc-2014-0035
- URN
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urn:nbn:de:101:1-2409241631528.390651989485
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ichikawa, Yuichi
- Nishimura, Yoshifumi
- Kurumizaka, Hitoshi
- Shimizu, Mitsuhiro
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Physical aspects of chromatin constituents : DNA dynamics and nucleosome positioning
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Mapping nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL
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