Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films

Abstract: In this study, composite nanofiber films for the wound dressing application were prepared with silk fibroin (SF) and polycaprolactone (PCL) by electrospinning techniques, and the SF/PCL composite nanofiber films were characterized by the combined techniques of scanning electron microscopy (SEM), the equilibrium water content, Fourier transform infrared spectrometer test, X-ray diffraction (XRD) and cell viability test. The results indicated several parameters, including the rotating roller speed, solution concentration, and SF/PCL ratio, affected SF/PCL composite nanofibers’ diameter size, distribution, and wettability. The SF/PCL composite nanofiber manifested a smaller fiber diameter and more uniform nanofibers than pure PCL nanofibers. The contact angle changed from 121 ± 2° of the neat pure PCL to full wetting of 40% SF/PCL composite nanofiber films at 2,000 rpm, indicating good hydrophilicity. Meanwhile, cells exhibit adhesion and proliferation on the composite nanofiber films. These results testified that SF/PCL composite nanofiber films may provide good wettability for cell adhesion and proliferation. It was suggested that optimized SF/PCL composite nanofiber films could be used as a potential biological dressing for skin wound healing.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Characterization, biocompatibility, and optimization of electrospun SF/PCL composite nanofiber films ; volume:62 ; number:1 ; year:2023 ; extent:9 ; Reviews on advanced materials science ; 62, Heft 1 (2023) (gesamt 9)

Contributors, Places and Time

• Creator: Feng, Yanping ; Jupei, Zhang ; Dong, Zhihong ; Tang, Lu

Further information

• DOI: 10.1515/rams-2022-0333
• URN: urn:nbn:de:101:1-2023071214151377396982
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:00 AM CEST