microRNA in the control of stem-like phenotype of cancer cells
Abstract: Current therapies against metastatic tumors are still ineffective. Cancer stem cells — a small subset of cells inside the tumor that possesses a self-renewal capacity — might be responsible for the recurrence of the tumor after anti-cancer therapies. Their immortality and unique drug resistance impede their eradication during therapy. The ‘stemness’ of these cells is controlled by microRNAs. These molecules possess the ability to downregulate gene expression by binding to the target mRNA. It turns out that microRNAs control the expression of approximately 60% of the genes in human cells. MicroRNA aberrant expression can lead to cancer development and progression. Therefore, recent research has focused on unraveling the role of microRNA in maintaining a stem-like phenotype in malignant tumors and cancer stem cells. This review summarizes our current knowledge about microRNAs that control the self-renewal capacity of cancer stem cells and indicates the importance of profound research aimed at developing efficient miRNA-targeted therapies.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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microRNA in the control of stem-like phenotype of cancer cells ; volume:8 ; number:10 ; year:2013 ; pages:931-942 ; extent:12
Open life sciences ; 8, Heft 10 (2013), 931-942 (gesamt 12)
- Creator
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Wozniak, Michal
- DOI
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10.2478/s11535-013-0222-9
- URN
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urn:nbn:de:101:1-2409211554470.327901926530
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:19 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wozniak, Michal
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MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation
MicroRNA-214-3p inhibits the stem-like properties of lung squamous cell cancer by targeting YAP1
Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens
Identification of Dysregulated microRNAs in Glioblastoma Stem-like Cells
The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells
BTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1
Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma
Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype
Circulating microRNA, secreted microRNA and exogenous plant microRNA
MicroRNA dynamics in mouse embryonic stem cells
Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells
MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation
MicroRNA-214-3p inhibits the stem-like properties of lung squamous cell cancer by targeting YAP1
Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens
Identification of Dysregulated microRNAs in Glioblastoma Stem-like Cells
The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells
BTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1
Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma
Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype
Circulating microRNA, secreted microRNA and exogenous plant microRNA
MicroRNA dynamics in mouse embryonic stem cells