Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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1 Online-Ressource.
- Language
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Englisch
- Bibliographic citation
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Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects ; volume:12 ; number:1 ; day:23 ; month:2 ; year:2024 ; pages:1-17 ; date:12.2024
Acta Neuropathologica Communications ; 12, Heft 1 (23.2.2024), 1-17, 12.2024
- Creator
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Markovinovic, Andrea
Martín-Guerrero, Sandra M.
Mórotz, Gábor M.
Salam, Shaakir
Gomez-Suaga, Patricia
Paillusson, Sebastien
Greig, Jenny
Lee, Younbok
Mitchell, Jacqueline C.
Noble, Wendy
Miller, Christopher C.J
- Contributor
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SpringerLink (Online service)
- DOI
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10.1186/s40478-024-01742-x
- URN
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urn:nbn:de:101:1-2404301308308.215992216211
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:45 AM CEST
Data provider
This object is provided by:
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Markovinovic, Andrea
- Martín-Guerrero, Sandra M.
- Mórotz, Gábor M.
- Salam, Shaakir
- Gomez-Suaga, Patricia
- Paillusson, Sebastien
- Greig, Jenny
- Lee, Younbok
- Mitchell, Jacqueline C.
- Noble, Wendy
- Miller, Christopher C.J
- SpringerLink (Online service)
Other Objects (12)
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Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
Tethering of hexokinase 2 to mitochondria promotes resistance of liver cancer cells to natural killer cell cytotoxicity
The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity
ALS/FTD ‐associated FUS activates GSK ‐3β to disrupt the VAPB – PTPIP 51 interaction and ER –mitochondria associations
Inflammation in ALS/FTD pathogenesis
Tethering complexes required for plant cytokinesis
Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes
Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies
Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases
α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production
FTD
Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled
Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
Tethering of hexokinase 2 to mitochondria promotes resistance of liver cancer cells to natural killer cell cytotoxicity
The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity
ALS/FTD ‐associated FUS activates GSK ‐3β to disrupt the VAPB – PTPIP 51 interaction and ER –mitochondria associations
Inflammation in ALS/FTD pathogenesis
Tethering complexes required for plant cytokinesis
Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes
Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies
Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases
α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production
FTD
Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled
Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
Tethering of hexokinase 2 to mitochondria promotes resistance of liver cancer cells to natural killer cell cytotoxicity
The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity
ALS/FTD ‐associated FUS activates GSK ‐3β to disrupt the VAPB – PTPIP 51 interaction and ER –mitochondria associations
Inflammation in ALS/FTD pathogenesis
Tethering complexes required for plant cytokinesis
Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes