When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease
Abstract: The regular overconsumption of energy‐dense foods (rich in lipids and sugars) results in elevated intestinal nutrient absorption and consequently excessive accumulation of lipids in the liver, adipose tissue, skeletal muscles, and other organs. This can eventually lead to obesity and obesity‐associated diseases such as type 2 diabetes (T2D), non‐alcoholic fatty liver disease (NAFLD), cardiovascular disease, and certain types of cancer, as well as aggravate inflammatory bowel disease (IBD). Therefore, targeting the pathways that regulate intestinal nutrient absorption holds significant therapeutic potential. In this review, we discuss the molecular and cellular mechanisms controlling intestinal lipid handling, their relevance to the development of metabolic diseases, and emerging therapeutic strategies.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease ; day:19 ; month:04 ; year:2022 ; extent:18
EMBO molecular medicine / European Molecular Biology Organization ; (19.04.2022) (gesamt 18)
- Creator
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Wit, Magdalena
Trujillo‐Viera, Jonathan
Strohmeyer, Akim
Klingenspor, Martin
Hankir, Mohammed
Sumara, Grzegorz
- DOI
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10.15252/emmm.202114742
- URN
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urn:nbn:de:101:1-2022041915071560535374
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:23 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wit, Magdalena
- Trujillo‐Viera, Jonathan
- Strohmeyer, Akim
- Klingenspor, Martin
- Hankir, Mohammed
- Sumara, Grzegorz
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