Selective Terminal Functionalization of Linear Alkanes **
Abstract: A two‐step sequential strategy involving a biocatalytic dehydrogenation/remote hydrofunctionalization, as a unified and versatile approach to selectively convert linear alkanes into a large array of valuable functionalized aliphatic derivatives is reported. The dehydrogenation is carried out by a mutant strain of a bacteria Rhodococcus and the produced alkenes are subsequently engaged in a remote functionalization through a metal‐catalyzed hydrometalation/migration sequence that subsequently react with a large variety of electrophiles. The judicious implementation of this combined biocatalytic and organometallic approach enabled us to develop a high‐yielding protocol to site‐selectively functionalize unreactive primary C−H bonds.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Selective Terminal Functionalization of Linear Alkanes ** ; day:15 ; month:06 ; year:2023 ; extent:6
Angewandte Chemie ; (15.06.2023) (gesamt 6)
- Creator
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Bruffaerts, Jeffrey
Kesten, Inbar
Buhnik‐Rosenblau, Keren
Cohen, Anthony
Edri, Nurit
Cormier, Morgan
Zhang, Yuanfei
Ho, Guo‐Ming
Massad, Itai
Halfon‐Verner, Hila
Kashi, Yechezkel
Marek, Ilan
- DOI
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10.1002/ange.202306343
- URN
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urn:nbn:de:101:1-2023061615023179399707
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:47 AM CEST
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Associated
- Bruffaerts, Jeffrey
- Kesten, Inbar
- Buhnik‐Rosenblau, Keren
- Cohen, Anthony
- Edri, Nurit
- Cormier, Morgan
- Zhang, Yuanfei
- Ho, Guo‐Ming
- Massad, Itai
- Halfon‐Verner, Hila
- Kashi, Yechezkel
- Marek, Ilan
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Selective Terminal Functionalization of Linear Alkanes **
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Interactive Bioconjugation at N ‐Terminal Cysteines by Using O ‐Salicylaldehyde Esters towards Dual Site‐Selective Functionalization
Selective C(sp3)–H arylation/alkylation of alkanes enabled by paired electrocatalysis
Highly Stable Subnanometric PtIn Clusters for the Selective Dehydrogenation of Alkanes
Nickel-Catalyzed anti-Selective Alkyne Functionalization Reactions
Selective electrochemical functionalization of the graphene edge
Selective N‐Deacetylation and Functionalization of Aminosugars
Type selective functionalization of single-walled carbon nanotubes
Selective Terminal Functionalization of Linear Alkanes **
Selective nitrogen insertion into aryl alkanes
Selective activation of lower alkanes : selective oxychlorination of methane and oxidative dehydrogenation of ethane
Soluble graphene through edge-selective functionalization
Highly Selective Nickel‐Catalyzed Isomerization‐Hydroboration of Alkenes Affords Terminal Functionalization at Remote C−H Position
Interactive Bioconjugation at N ‐Terminal Cysteines by Using O ‐Salicylaldehyde Esters towards Dual Site‐Selective Functionalization
Selective C(sp3)–H arylation/alkylation of alkanes enabled by paired electrocatalysis
Highly Stable Subnanometric PtIn Clusters for the Selective Dehydrogenation of Alkanes
Nickel-Catalyzed anti-Selective Alkyne Functionalization Reactions
Selective electrochemical functionalization of the graphene edge
Selective N‐Deacetylation and Functionalization of Aminosugars
Type selective functionalization of single-walled carbon nanotubes
Selective Terminal Functionalization of Linear Alkanes **
Selective nitrogen insertion into aryl alkanes
Selective activation of lower alkanes : selective oxychlorination of methane and oxidative dehydrogenation of ethane
Soluble graphene through edge-selective functionalization
Highly Selective Nickel‐Catalyzed Isomerization‐Hydroboration of Alkenes Affords Terminal Functionalization at Remote C−H Position
Interactive Bioconjugation at N ‐Terminal Cysteines by Using O ‐Salicylaldehyde Esters towards Dual Site‐Selective Functionalization
Selective C(sp3)–H arylation/alkylation of alkanes enabled by paired electrocatalysis
Highly Stable Subnanometric PtIn Clusters for the Selective Dehydrogenation of Alkanes
Nickel-Catalyzed anti-Selective Alkyne Functionalization Reactions
Selective electrochemical functionalization of the graphene edge
Selective N‐Deacetylation and Functionalization of Aminosugars