Membrane Manipulation of Giant Unilamellar Polymer Vesicles with a Temperature‐Responsive Polymer

Abstract: Understanding the complex behavior and dynamics of cellular membranes is integral to gain insight into cellular division and fusion processes. Bottom‐up synthetic cells are as a platform for replicating and probing cellular behavior. Giant polymer vesicles are more robust than liposomal counterparts, as well as having a broad range of chemical functionalities. However, the stability of the membrane can prohibit dynamic processes such as membrane phase separation and division. Here, we present a method for manipulating the membrane of giant polymersomes using a temperature responsive polymer. Upon elevation of temperature deformation and phase separation of the membrane was observed. Upon cooling, the membrane relaxed and became homogeneous again, with infrequent division of the synthetic cells.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Membrane Manipulation of Giant Unilamellar Polymer Vesicles with a Temperature‐Responsive Polymer ; day:23 ; month:08 ; year:2022 ; extent:1 ; Angewandte Chemie / International edition. International edition ; (23.08.2022) (gesamt 1)

Contributors, Places and Time

• Creator: de Souza Melchiors, Marina ; Ivanov, Tsvetomir ; Harley, Iain ; Sayer, Claudia ; Araújo, Pedro H. H. ; Caire da Silva, Lucas ; Ferguson, Calum T. J. ; Landfester, Katharina

Further information

• DOI: 10.1002/anie.202207998
• URN: urn:nbn:de:101:1-2022082315190357763754
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:34 AM CEST