Interplay between lncRNA/miRNA and Wnt/β-catenin signaling in brain cancer tumorigenesis

Abstract: Brain cancers are among the most aggressive malignancies with high mortality and morbidity worldwide. The pathogenesis of brain cancers is a very complicated process involving various genetic mutations affecting several oncogenic signaling pathways like Wnt/β-catenin axis. Uncontrolled activation of this oncogenic signaling is associated with decreased survival rate and poor prognosis in cancer patients. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) were shown to play important roles in regulating cell proliferation, differentiation, and apoptosis by regulating the expression of their target genes. Aberrant expression of these non-coding RNAs (ncRNAs) was reported in many human cancers, including glioblastoma, medulloblastoma, meningioma, and pituitary adenoma. Multiple lncRNAs were shown to participate in brain tumor pathogenesis by targeting Wnt signaling regulatory miRNAs. SNHG7/miR-5095, PCAT6/miR-139-3p, SNHG6/miR-944, SNHG1/ miR-556‐5p, SNHG17/ miR-506-3p, LINC00702/m.... https://www.excli.de/excli/article/view/6490

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Interplay between lncRNA/miRNA and Wnt/β-catenin signaling in brain cancer tumorigenesis ; volume:22 ; year:2023 ; EXCLI journal ; 22 (2023)

Contributors, Places and Time

• Creator: Rahmani, Farzad ; Mohammed Al-Asady, Abdulridha ; Hanaie, Reyhane ; Zandigohar, Mehrdad ; Faridnejad, Homeira ; Payazdan, Mahya ; Safavi, Pegah ; Ryzhikov, Mikhail ; Hassanian, Seyed Mahdi

Further information

• DOI: 10.17179/excli2023-6490
• URN: urn:nbn:de:101:1-2501170217433.419968565820
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:34 AM CEST