Emerging principles of primary cilia dynamics in controlling tissue organization and function
Abstract: Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context-dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell- and tissue-specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
The EMBO journal. - 42, 21 (2023) , e113891, ISSN: 1460-2075
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2023
- DOI
-
10.15252/embj.2023113891
- URN
-
urn:nbn:de:bsz:25-freidok-2416143
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
25.03.2025, 1:43 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Time of origin
- 2023
Other Objects (12)
The role of primary cilia in skeletal muscle
Cilia-dependent signaling pathways controlling adipose tissue plasticity
Loss of cilia in primary ciliated cells and multiciliated cells
Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer
Characterization of primary cilia in patient-derived glioma stem cells
Primary cilia are dysfunctional in obese adipose-derived mesenchymal stem cells
The role of primary cilia in neuronal homeostasis and in neurodegenerative diseases
PIP₂ determines length and stability of primary cilia by balancing membrane turnovers
PIP2 determines length and stability of primary cilia by balancing membrane turnovers
Portuguese intermunicipal organization - Basic principles
Primary cilia and their effects on immune cell functions and metabolism : a model
Soft tissue augmentation : principles and practice
The role of primary cilia in skeletal muscle
Cilia-dependent signaling pathways controlling adipose tissue plasticity
Loss of cilia in primary ciliated cells and multiciliated cells
Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer
Characterization of primary cilia in patient-derived glioma stem cells
Primary cilia are dysfunctional in obese adipose-derived mesenchymal stem cells
The role of primary cilia in neuronal homeostasis and in neurodegenerative diseases
PIP₂ determines length and stability of primary cilia by balancing membrane turnovers
PIP2 determines length and stability of primary cilia by balancing membrane turnovers
Portuguese intermunicipal organization - Basic principles
Primary cilia and their effects on immune cell functions and metabolism : a model
Soft tissue augmentation : principles and practice
The role of primary cilia in skeletal muscle
Cilia-dependent signaling pathways controlling adipose tissue plasticity
Loss of cilia in primary ciliated cells and multiciliated cells
Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer
Characterization of primary cilia in patient-derived glioma stem cells
Primary cilia are dysfunctional in obese adipose-derived mesenchymal stem cells
The role of primary cilia in neuronal homeostasis and in neurodegenerative diseases
PIP₂ determines length and stability of primary cilia by balancing membrane turnovers
PIP2 determines length and stability of primary cilia by balancing membrane turnovers
Portuguese intermunicipal organization - Basic principles
Primary cilia and their effects on immune cell functions and metabolism : a model