Pacemakers and methylprednisolone pulse therapy in immune-related myocarditis concomitant with complete heart block
Abstract: Immune-related cardiotoxicities are uncommon but potentially fatal. The study aims to evaluate the value of pacemakers and methylprednisolone pulse therapy (MPPT) to patients with immune-related myocarditis concomitant with complete heart block (CHB). We first reviewed medical records of three patients with immune-related myocarditis concomitant with CHB. For the pooled analysis, we searched related cases with immune-related myocarditis in the PubMed database and screened the patients. Clinical characteristics, management, and outcomes were summarized. Our three patients developed immune-related myocarditis concomitant with CHB about 2 weeks after receiving pembrolizumab, and were successfully treated with pacemaker implantation and high-dose steroids (two received MPPT). In the pooled analysis, 21 cases were eligible with an overall fatality rate of 52%. Patients with pacemakers had a fatality rate of 38%, significantly lower than patients without them (38% vs 100%; p = 0.035), particularly the MPPT subgroup (25% vs 100%; p = 0.019). All five patients without pacemakers expired. Among patients with pacemakers, MPPT patients tended to have an inferior rate compared with non-MPPT patients. Timely pacemaker implantation played a crucial role in improving the outcomes of patients with immune-related myocarditis concomitant with CHB. Patients receiving MPPT appeared to have a better prognosis. Additionally, multidisciplinary consultation should be recommended for better management.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Pacemakers and methylprednisolone pulse therapy in immune-related myocarditis concomitant with complete heart block ; volume:17 ; number:1 ; year:2022 ; pages:2109-2116 ; extent:8
Open medicine ; 17, Heft 1 (2022), 2109-2116 (gesamt 8)
- Urheber
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Hu, Chunhong
Zhao, Lishu
Zhou, Chengzhi
Wang, Hanping
Jiang, Shun
Li, Yizheng
Peng, Yurong
Deng, Chao
Ma, Fang
Pan, Yue
Shu, Long
Huang, Yan
Zeng, Yue
Wu, Fang
- DOI
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10.1515/med-2022-0611
- URN
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urn:nbn:de:101:1-2022122113054321227465
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:33 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Hu, Chunhong
- Zhao, Lishu
- Zhou, Chengzhi
- Wang, Hanping
- Jiang, Shun
- Li, Yizheng
- Peng, Yurong
- Deng, Chao
- Ma, Fang
- Pan, Yue
- Shu, Long
- Huang, Yan
- Zeng, Yue
- Wu, Fang
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