STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition

to related objects

Abstract: Stromal antigen 2 (STAG2), a subunit of the cohesin complex, is recurrently mutated in various tumors. However, the role of STAG2 in DNA repair and its therapeutic implications are largely unknown. Here it is reported that knockout of STAG2 results in increased double‐stranded breaks (DSBs) and chromosomal aberrations by reducing homologous recombination (HR) repair, and confers hypersensitivity to inhibitors of ataxia telangiectasia mutated (ATMi), Poly ADP Ribose Polymerase (PARPi), or the combination of both. Of note, the impaired HR by STAG2‐deficiency is mainly attributed to the restored expression of KMT5A, which in turn methylates H4K20 (H4K20me0) to H4K20me1 and thereby decreases the recruitment of BRCA1‐BARD1 to chromatin. Importantly, STAG2 expression correlates with poor prognosis of cancer patients. STAG2 is identified as an important regulator of HR and a potential therapeutic strategy for STAG2‐mutant tumors is elucidated.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition ; day:20 ; month:11 ; year:2023 ; extent:16
Advanced science ; (20.11.2023) (gesamt 16)

Creator: Zhou, Jie
Nie, Run‐Cong
He, Zhang‐Ping
Cai, Xiao‐Xia
Chen, Jie‐Wei
Lin, Wen‐ping
Yin, Yi‐Xin
Xiang, Zhi‐Cheng
Zhu, Tian‐Chen
Xie, Juan‐Juan
Zhang, You‐Cheng
Wang, Xin
Lin, Peng
Xie, Dan
D'Andrea, Alan D.
Cai, Mu‐Yan

DOI: 10.1002/advs.202302494

URN: urn:nbn:de:101:1-2023112114472191813185

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:27 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Zhou, Jie
Nie, Run‐Cong
He, Zhang‐Ping
Cai, Xiao‐Xia
Chen, Jie‐Wei
Lin, Wen‐ping
Yin, Yi‐Xin
Xiang, Zhi‐Cheng
Zhu, Tian‐Chen
Xie, Juan‐Juan
Zhang, You‐Cheng
Wang, Xin
Lin, Peng
Xie, Dan
D'Andrea, Alan D.
Cai, Mu‐Yan

Other Objects (12)

Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures

Tunable Phase Distribution of Liquid Metamaterial

$Semicontinuity of 4d N = 2 $$ \mathcalN}=2 $$ spectrum under renormalization group flow$

Semicontinuity of 4d N = 2 $$ \mathcalN}=2 $$ spectrum under renormalization group flow

$A study of N $$ \mathcalN} $$ = 1 SCFT derived from N $$ \mathcalN} $$ = 2 SCFT: index and chiral ring$

A study of N $$ \mathcalN} $$ = 1 SCFT derived from N $$ \mathcalN} $$ = 2 SCFT: index and chiral ring

$The moduli space of vacua of N = 2 $$ \mathcalN}=2 $$ class S $$ \mathcalS} $$ theories$

The moduli space of vacua of N = 2 $$ \mathcalN}=2 $$ class S $$ \mathcalS} $$ theories

$W algebras, cosets and VOAs for 4d N $$ \mathcalN} $$ = 2 SCFTs from M5 branes$

W algebras, cosets and VOAs for 4d N $$ \mathcalN} $$ = 2 SCFTs from M5 branes

Argyres-Douglas matter and S-duality. Part II

$Three dimensional canonical singularity and five dimensional N $$ \mathcalN} $$ = 1 SCFT$

Three dimensional canonical singularity and five dimensional N $$ \mathcalN} $$ = 1 SCFT

$4d N $$ \mathcalN} $$ = 2 SCFTs and lisse W-algebras$

4d N $$ \mathcalN} $$ = 2 SCFTs and lisse W-algebras

Arbeitspapier

Household Stockholding Behavior During the Great Financial Crisis

Synthetic Methodologies for Si‐Containing Li‐Storage Electrode Materials

Clinical efficacy of 5-hydroxytryptamine 3 receptor antagonists in reducing propofol injection pain, postoperative nausea/vomiting and shivering: A meta-analysis

Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures

Tunable Phase Distribution of Liquid Metamaterial

$Semicontinuity of 4d N = 2 $$ \mathcalN}=2 $$ spectrum under renormalization group flow$

Semicontinuity of 4d N = 2 $$ \mathcalN}=2 $$ spectrum under renormalization group flow

$A study of N $$ \mathcalN} $$ = 1 SCFT derived from N $$ \mathcalN} $$ = 2 SCFT: index and chiral ring$

A study of N $$ \mathcalN} $$ = 1 SCFT derived from N $$ \mathcalN} $$ = 2 SCFT: index and chiral ring

$The moduli space of vacua of N = 2 $$ \mathcalN}=2 $$ class S $$ \mathcalS} $$ theories$

The moduli space of vacua of N = 2 $$ \mathcalN}=2 $$ class S $$ \mathcalS} $$ theories

$W algebras, cosets and VOAs for 4d N $$ \mathcalN} $$ = 2 SCFTs from M5 branes$

W algebras, cosets and VOAs for 4d N $$ \mathcalN} $$ = 2 SCFTs from M5 branes

Argyres-Douglas matter and S-duality. Part II

$Three dimensional canonical singularity and five dimensional N $$ \mathcalN} $$ = 1 SCFT$

Three dimensional canonical singularity and five dimensional N $$ \mathcalN} $$ = 1 SCFT

$4d N $$ \mathcalN} $$ = 2 SCFTs and lisse W-algebras$

4d N $$ \mathcalN} $$ = 2 SCFTs and lisse W-algebras

Arbeitspapier

Household Stockholding Behavior During the Great Financial Crisis

Synthetic Methodologies for Si‐Containing Li‐Storage Electrode Materials

Clinical efficacy of 5-hydroxytryptamine 3 receptor antagonists in reducing propofol injection pain, postoperative nausea/vomiting and shivering: A meta-analysis

Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures

Tunable Phase Distribution of Liquid Metamaterial

$Semicontinuity of 4d N = 2 $$ \mathcalN}=2 $$ spectrum under renormalization group flow$

Semicontinuity of 4d N = 2 $$ \mathcalN}=2 $$ spectrum under renormalization group flow

$A study of N $$ \mathcalN} $$ = 1 SCFT derived from N $$ \mathcalN} $$ = 2 SCFT: index and chiral ring$

A study of N $$ \mathcalN} $$ = 1 SCFT derived from N $$ \mathcalN} $$ = 2 SCFT: index and chiral ring

$The moduli space of vacua of N = 2 $$ \mathcalN}=2 $$ class S $$ \mathcalS} $$ theories$

The moduli space of vacua of N = 2 $$ \mathcalN}=2 $$ class S $$ \mathcalS} $$ theories

$W algebras, cosets and VOAs for 4d N $$ \mathcalN} $$ = 2 SCFTs from M5 branes$

W algebras, cosets and VOAs for 4d N $$ \mathcalN} $$ = 2 SCFTs from M5 branes

Argyres-Douglas matter and S-duality. Part II

$Three dimensional canonical singularity and five dimensional N $$ \mathcalN} $$ = 1 SCFT$

Three dimensional canonical singularity and five dimensional N $$ \mathcalN} $$ = 1 SCFT

$4d N $$ \mathcalN} $$ = 2 SCFTs and lisse W-algebras$

4d N $$ \mathcalN} $$ = 2 SCFTs and lisse W-algebras

Arbeitspapier

Household Stockholding Behavior During the Great Financial Crisis

Synthetic Methodologies for Si‐Containing Li‐Storage Electrode Materials

Clinical efficacy of 5-hydroxytryptamine 3 receptor antagonists in reducing propofol injection pain, postoperative nausea/vomiting and shivering: A meta-analysis

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition

Object Details

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures

Tunable Phase Distribution of Liquid Metamaterial

Semicontinuity of 4d N = 2 $$ \mathcalN}=2 $$ spectrum under renormalization group flow

A study of N $$ \mathcalN} $$ = 1 SCFT derived from N $$ \mathcalN} $$ = 2 SCFT: index and chiral ring

The moduli space of vacua of N = 2 $$ \mathcalN}=2 $$ class S $$ \mathcalS} $$ theories

W algebras, cosets and VOAs for 4d N $$ \mathcalN} $$ = 2 SCFTs from M5 branes

Argyres-Douglas matter and S-duality. Part II

Three dimensional canonical singularity and five dimensional N $$ \mathcalN} $$ = 1 SCFT

4d N $$ \mathcalN} $$ = 2 SCFTs and lisse W-algebras

Household Stockholding Behavior During the Great Financial Crisis

Synthetic Methodologies for Si‐Containing Li‐Storage Electrode Materials

Clinical efficacy of 5-hydroxytryptamine 3 receptor antagonists in reducing propofol injection pain, postoperative nausea/vomiting and shivering: A meta-analysis

Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures

Tunable Phase Distribution of Liquid Metamaterial

Semicontinuity of 4d N = 2 $$ \mathcalN}=2 $$ spectrum under renormalization group flow

A study of N $$ \mathcalN} $$ = 1 SCFT derived from N $$ \mathcalN} $$ = 2 SCFT: index and chiral ring

The moduli space of vacua of N = 2 $$ \mathcalN}=2 $$ class S $$ \mathcalS} $$ theories

W algebras, cosets and VOAs for 4d N $$ \mathcalN} $$ = 2 SCFTs from M5 branes

Argyres-Douglas matter and S-duality. Part II

Three dimensional canonical singularity and five dimensional N $$ \mathcalN} $$ = 1 SCFT

4d N $$ \mathcalN} $$ = 2 SCFTs and lisse W-algebras

Household Stockholding Behavior During the Great Financial Crisis

Synthetic Methodologies for Si‐Containing Li‐Storage Electrode Materials

Clinical efficacy of 5-hydroxytryptamine 3 receptor antagonists in reducing propofol injection pain, postoperative nausea/vomiting and shivering: A meta-analysis

Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures

Tunable Phase Distribution of Liquid Metamaterial

Semicontinuity of 4d N = 2 $$ \mathcalN}=2 $$ spectrum under renormalization group flow

A study of N $$ \mathcalN} $$ = 1 SCFT derived from N $$ \mathcalN} $$ = 2 SCFT: index and chiral ring

The moduli space of vacua of N = 2 $$ \mathcalN}=2 $$ class S $$ \mathcalS} $$ theories

W algebras, cosets and VOAs for 4d N $$ \mathcalN} $$ = 2 SCFTs from M5 branes

Argyres-Douglas matter and S-duality. Part II

Three dimensional canonical singularity and five dimensional N $$ \mathcalN} $$ = 1 SCFT

4d N $$ \mathcalN} $$ = 2 SCFTs and lisse W-algebras

Household Stockholding Behavior During the Great Financial Crisis

Synthetic Methodologies for Si‐Containing Li‐Storage Electrode Materials

Clinical efficacy of 5-hydroxytryptamine 3 receptor antagonists in reducing propofol injection pain, postoperative nausea/vomiting and shivering: A meta-analysis

Related objects

Reset password