HER2-Positive Lacrimal Sac Squamous Cell Carcinoma in a 57-Year-Old Man
Abstract: Introduction: Lacrimal sac squamous cell carcinoma (SCC) is a rare tumor. Only 241 cases of lacrimal sac SCC have been reported in the literature. However, the detailed molecular profile of this tumor is unknown. Case Presentation: Fifty-seven-year-old Caucasian male presented with a 6-month history of epiphora. Multimodal examination revealed a unilateral lacrimal sac SCC T4aN0M0. The patient underwent primary surgery with subsequent chemoradiotherapy. The patient was alive 18 months after the end of the treatment, with no signs of local or distant relapse. Complex molecular profiling revealed the FGFR p.G388R variant, HER2 amplification, and progression phenotype. Conclusion: Here, we describe a clinical case of a male patient with lacrimal sac SCC with a careful description of the disease history, treatment, and molecular-genetic patterns of the tumor. This is the first report of HER2-positive lacrimal sac SCC.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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HER2-Positive Lacrimal Sac Squamous Cell Carcinoma in a 57-Year-Old Man ; volume:17 ; number:1 ; year:2024 ; pages:142-149 ; extent:8
Case reports in oncology ; 17, Heft 1 (2024), 142-149 (gesamt 8)
- Urheber
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Grachev, Nikolay
Rabaev, Gavriil
Avdalyan, Ashot
Znamenskiy, Igor
Mosin, Dmitry
Ustyuzhanin, Dmitry
Rabaev, Gennady
Lužbeták, Martin
- DOI
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10.1159/000536061
- URN
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urn:nbn:de:101:1-2406270101553.076440634551
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:44 MESZ
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Beteiligte
- Grachev, Nikolay
- Rabaev, Gavriil
- Avdalyan, Ashot
- Znamenskiy, Igor
- Mosin, Dmitry
- Ustyuzhanin, Dmitry
- Rabaev, Gennady
- Lužbeták, Martin
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