An Epigenetics‐Inspired DNA‐Based Data Storage System

Abstract: Biopolymers are an attractive alternative to store and circulate information. DNA, for example, combines remarkable longevity with high data storage densities and has been demonstrated as a means for preserving digital information. Inspired by the dynamic, biological regulation of (epi) genetic information, we herein present how binary data can undergo controlled changes when encoded in synthetic DNA strands. By exploiting differential kinetics of hydrolytic deamination reactions of cytosine and its naturally occurring derivatives, we demonstrate how multiple layers of information can be stored in a single DNA template. Moreover, we show that controlled redox reactions allow for interconversion of these DNA‐encoded layers of information. Overall, such interlacing of multiple messages on synthetic DNA libraries showcases the potential of chemical reactions to manipulate digital information on (bio) polymers.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: An Epigenetics‐Inspired DNA‐Based Data Storage System ; volume:55 ; number:37 ; year:2016 ; pages:11144-11148 ; extent:5 ; Angewandte Chemie / International edition. International edition ; 55, Heft 37 (2016), 11144-11148 (gesamt 5)

Contributors, Places and Time

• Creator: Mayer, Clemens ; McInroy, Gordon R. ; Murat, Pierre ; Van Delft, Pieter ; Balasubramanian, Shankar

Further information

• DOI: 10.1002/anie.201605531
• URN: urn:nbn:de:101:1-2022101107353138486651
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:22 AM CEST