Enantiospecific Synthesis and Cytotoxicity Evaluation of Oximidine II Analogues
Abstract: Analogues of the anticancer natural product oximidine II were prepared and evaluated for cytotoxicity. One analogue of oximidine II that carries a C15 allylic amide side chain as well as two analogues with C15 vinyl sulfone side chains were found to lack cytotoxicity against the cancer cell line SK‐Mel‐5, thereby confirming the necessity of the C15 enamide side chain of oximidine II for cytotoxicity. Four analogues, designed by comparative molecular similarity index analysis (CoMSIA), that feature a less complex macrolactone scaffold were prepared and tested. The two analogues carrying a C15 vinyl sulfone group and the two analogues with a C15 oximidine II enamide side chain showed weak cytotoxicity against the SK‐Mel‐5 cell line and other cell lines, indicating that the designed simplified macrocycles cannot replace the oximidine II macrocycle.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Enantiospecific Synthesis and Cytotoxicity Evaluation of Oximidine II Analogues ; volume:11 ; number:15 ; year:2016 ; pages:1600-1616 ; extent:17
ChemMedChem ; 11, Heft 15 (2016), 1600-1616 (gesamt 17)
- Creator
- DOI
-
10.1002/cmdc.201600024
- URN
-
urn:nbn:de:101:1-2022110706502047185258
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:21 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Schneider, Christopher M.
- Li, Wei
- Khownium, Kriangsak
- Lushington, Gerald H.
- Georg, Gunda I.
Other Objects (12)
Structural analysis of bacterial and viral infections and a cysteine proteinase legumain
Grafische Simulation und Kollisionsvermeidung von Robotern
Chiral algebra from worldsheet
Multifunctional charge transfer plasmon resonance sensors
Global smooth solution to the n -dimensional liquid crystal equations with fractional dissipation
Reduced surface fine dust under droughts over the southeastern United States during summertime: observations and CMIP6 model simulations
Observed and CMIP6 model simulated organic aerosol response to drought in the contiguous United States during summertime
Gluing affine Yangians with bi-fundamentals
microRNA-15 Activates NF-κB Pathway via Down Regulating Expression of Adenosine A2 Receptor in Ulcerative Colitis
Stability Analysis of a Slurry Trench in Cohesive-Frictional Soils
Performance degradation detection method of aeroengine fuel metering device
Quiver algebras and their representations for arbitrary quivers
Structural analysis of bacterial and viral infections and a cysteine proteinase legumain
Grafische Simulation und Kollisionsvermeidung von Robotern
Chiral algebra from worldsheet
Multifunctional charge transfer plasmon resonance sensors
Global smooth solution to the n -dimensional liquid crystal equations with fractional dissipation
Reduced surface fine dust under droughts over the southeastern United States during summertime: observations and CMIP6 model simulations
Observed and CMIP6 model simulated organic aerosol response to drought in the contiguous United States during summertime
Gluing affine Yangians with bi-fundamentals
microRNA-15 Activates NF-κB Pathway via Down Regulating Expression of Adenosine A2 Receptor in Ulcerative Colitis
Stability Analysis of a Slurry Trench in Cohesive-Frictional Soils
Performance degradation detection method of aeroengine fuel metering device
Quiver algebras and their representations for arbitrary quivers
Structural analysis of bacterial and viral infections and a cysteine proteinase legumain
Grafische Simulation und Kollisionsvermeidung von Robotern
Chiral algebra from worldsheet
Multifunctional charge transfer plasmon resonance sensors
Global smooth solution to the n -dimensional liquid crystal equations with fractional dissipation
Reduced surface fine dust under droughts over the southeastern United States during summertime: observations and CMIP6 model simulations
Observed and CMIP6 model simulated organic aerosol response to drought in the contiguous United States during summertime
Gluing affine Yangians with bi-fundamentals
microRNA-15 Activates NF-κB Pathway via Down Regulating Expression of Adenosine A2 Receptor in Ulcerative Colitis
Stability Analysis of a Slurry Trench in Cohesive-Frictional Soils
Performance degradation detection method of aeroengine fuel metering device