Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome via suppressing Tfh cell response
Objectives: To investigate the effect of olfactory ecto-mesenchymal stem cell-derived exosomes (OE-MSC-Exos) on T follicular helper (Tfh) cell response and their implication in treating experimental Sjögrens syndrome (ESS). Methods: C57BL/6 mice were immunized with salivary glands (SG) proteins to induce ESS mouse model. OE-MSC-Exos were added to the Tfh cell polarization condition, and the proportion of Tfh cells was detected by FCM. The PD-L1 of OE-MSCs was silenced with small interfering RNA to extract siPD-L1-OE-MSC-Exos. Results: We found that transfer of OE-MSC-Exos markedly attenuated disease progression and reduced Tfh cell response in mice with ESS. In culture, OE-MSC-Exos potently inhibited the differentiation of Tfh cells from naïve T cells. Moreover, OE-MSC-Exos expressed high level of the ligand for the programmed cell death protein 1 (PD-L1), knocking down PD-L1 expression in OE-MSC-Exos significantly decreased their capacity to suppress Tfh cell differentiation in vitro. Consistently, transfer of OE-MSC-Exos with PD-L1 knockdown exhibited profoundly diminished therapeutic effect in ESS mice, accompanied with sustained Tfh cell response and high levels of autoantibody production. Conclusion: Our results suggest that OE-MSC-Exos may exert their therapeutic effect in ameliorating ESS progression via suppressing Tfh cell response in a PD-L1-dependent manner.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome via suppressing Tfh cell response ; volume:3 ; number:4 ; year:2022 ; pages:198-207 ; extent:10
Rheumatology and immunology research ; 3, Heft 4 (2022), 198-207 (gesamt 10)
- Creator
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Rui, Ke
Shen, Ziwei
Peng, Na
Zhao, Futao
Tang, Yuan
Liu, Shiyi
Xu, Xinyi
Liu, Chang
Wu, Ling
Tian, Jie
Lu, Liwei
- DOI
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10.2478/rir-2022-0035
- URN
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urn:nbn:de:101:1-2023020813065407224615
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:54 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Rui, Ke
- Shen, Ziwei
- Peng, Na
- Zhao, Futao
- Tang, Yuan
- Liu, Shiyi
- Xu, Xinyi
- Liu, Chang
- Wu, Ling
- Tian, Jie
- Lu, Liwei
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