Leveraging omics to understand the molecular basis of acute-on-chronic liver failure

Abstract: Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we describe how omic technologies have contributed to the characterization of the hyperinflammatory state in patients with acutely decompensated cirrhosis developing ACLF, with special emphasis on the role of metabolomics, lipidomics and transcriptomics in profiling the triggers (pathogen- and damage-associated molecular patterns [PAMPs and DAMPs]) and effector molecules (cytokines, chemokines, growth factors and bioactive lipid mediators) that lead to activation of the innate immune system. This review also describes how omic approaches can be invaluable tools to accelerate the identification of novel biomarkers that could guide the implementation of novel therapies/interventions aimed at protecting these patients from excessive systemic inflammation and organ failure.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Leveraging omics to understand the molecular basis of acute-on-chronic liver failure ; volume:2 ; number:4 ; year:2021 ; pages:516-527 ; extent:12 ; Advances in laboratory medicine ; 2, Heft 4 (2021), 516-527 (gesamt 12)

Contributors, Places and Time

• Creator: Clària, Joan

Further information

• DOI: 10.1515/almed-2021-0023
• URN: urn:nbn:de:101:1-2023040814165570008434
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:47 AM CEST