Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications

Abstract: Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into the extracellular environment. Recent studies have shown that EVs serve as “messengers” in intercellular and inter‐organismal communication, in both normal and pathological processes. EVs, as natural nanocarriers, can deliver bioactivators in therapy with their endogenous transport properties. This review article describes the engineering EVs of sources, isolation method, cargo loading, boosting approach, and adjustable targeting of EVs. Furthermore, the review summarizes the recent progress made in EV‐based delivery systems applications, including cancer, cardiovascular diseases, liver, kidney, nervous system diseases, and COVID‐19 and emphasizes the obstacles and challenges of EV‐based therapies and possible strategies.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications ; volume:10 ; number:17 ; year:2023 ; extent:21
Advanced science ; 10, Heft 17 (2023) (gesamt 21)

Creator
Wang, Liwei
Wang, Di
Ye, Zhaoming
Xu, Jianbin

DOI
10.1002/advs.202300552
URN
urn:nbn:de:101:1-2023061416013637310502
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
14.08.2025, 10:47 AM CEST

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Associated

  • Wang, Liwei
  • Wang, Di
  • Ye, Zhaoming
  • Xu, Jianbin

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