Best‐Practice DFT Protocols for Basic Molecular Computational Chemistry **
Abstract: Nowadays, many chemical investigations are supported by routine calculations of molecular structures, reaction energies, barrier heights, and spectroscopic properties. The lion's share of these quantum‐chemical calculations applies density functional theory (DFT) evaluated in atomic‐orbital basis sets. This work provides best‐practice guidance on the numerous methodological and technical aspects of DFT calculations in three parts: Firstly, we set the stage and introduce a step‐by‐step decision tree to choose a computational protocol that models the experiment as closely as possible. Secondly, we present a recommendation matrix to guide the choice of functional and basis set depending on the task at hand. A particular focus is on achieving an optimal balance between accuracy, robustness, and efficiency through multi‐level approaches. Finally, we discuss selected representative examples to illustrate the recommended protocols and the effect of methodological choices.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Best‐Practice DFT Protocols for Basic Molecular Computational Chemistry ** ; day:14 ; month:09 ; year:2022 ; extent:1
Angewandte Chemie ; (14.09.2022) (gesamt 1)
- Creator
- DOI
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10.1002/ange.202205735
- URN
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urn:nbn:de:101:1-2022091515020906925374
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:31 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Bursch, Markus
- Mewes, Jan-Michael
- Hansen, Andreas
- Grimme, Stefan
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Best‐Practice DFT Protocols for Basic Molecular Computational Chemistry **
Acylation Reactions of Dibenzo‐7‐phosphanorbornadiene: DFT Mechanistic Insights
LiAlH 4 ‐catalyzed Imine Hydrogenation with Dihydrogen: New DFT Mechanistic Insights
Frustrated Lewis Pair Catalyzed Reduction of Carbon Dioxide Using Hydroboranes: New DFT Mechanistic Insights
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Hydrocarbon Macrocycle Conformer Ensembles and 13 C‐NMR Spectra
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Best‐Practice DFT Protocols for Basic Molecular Computational Chemistry **
Acylation Reactions of Dibenzo‐7‐phosphanorbornadiene: DFT Mechanistic Insights
LiAlH 4 ‐catalyzed Imine Hydrogenation with Dihydrogen: New DFT Mechanistic Insights
Frustrated Lewis Pair Catalyzed Reduction of Carbon Dioxide Using Hydroboranes: New DFT Mechanistic Insights
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Robust Atomistic Modeling of Materials, Organometallic, and Biochemical Systems
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Hydrocarbon Macrocycle Conformer Ensembles and 13 C‐NMR Spectra
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